中药复方溃疡油防治放射性皮肤炎的临床观察  

Clinical observation of treatment of radiation dermatitis by the ulcer oil of chinese herbs compound

作　　者：赵瑞莲[1] 沈红梅[1] 张明[2] 周映伽[1] 阮艳玲[1] 

机构地区：[1]云南省肿瘤医院中西医结合科,昆明650118 [2]云南省肿瘤医院放疗科,昆明650118

出　　处：《重庆医学》2016年第25期3488-3490,共3页Chongqing medicine

基　　金：云南省卫生内设研究机构项目(2011ws0064);云南省应用基础研究昆医联合专项(2013FB175)

摘　　要：目的探讨中药复方溃疡油防治放射性皮肤炎的疗效。方法将接受头、颈、胸部位放射治疗的患者80例分为溃疡油组(观察组)和西医治疗组(对照组),每组40例。观察两组放疗性皮肤损伤出现时间、皮肤损伤分级、皮肤损伤痊愈时间等。通过卡式(KPS)评分和皮肤病生活质量指标调查表(DLQI)评分比较两组患者生活质量。结果两组的放射性皮肤炎发生率为100%,观察组的患者皮肤炎出现时间较对照组有明显延缓(P<0.05)。观察组中发生1、2级皮肤炎的人数占到90%,而对照组中发生1、2级皮肤炎的人数为42.5%,观察组的放射性皮肤炎级别总体低于对照组(P<0.05)。对照组的平均痊愈时间为(24.70±2.64)d,观察组的平均痊愈时间为(26.50±2.64)d,差异有统计学意义(P<0.01)。两组患者放疗前KPS评分和DLQI评分差异均无统计学意义(P>0.05),放疗后观察组KPS评分均明显高于对照组(P<0.01),DLQI评分明显低于对照组(P<0.01)。结论中药复方溃疡油能明显地延缓患者放射性皮肤炎发生的时间,降低患者放射性皮肤炎级别,而且加速皮肤损伤的愈合,对患者的生活质量有整体改善作用。Objective To evaluate the efficacy of ulcer oil of chinese herbs compound in the treatment of radiation dermatitis. Methods Totally 80 patients who received radiotherapy were prospectively enrolled in this study and randomly assigned to the ul- cer oil group（observation group） and western medicine group （control group） ,40 cases in each group. The occurrence time of radia- tion induced skin damage, the grade of skin damage, the completion rate of radiotherapy, the healing rime and the treatment efficien- cy of skin injury were observed. The KPS score and dermatology life quality index questionnaire （DLQI） were observed and com- pared for quality of life. Results Dermatitis incidence rate of two groups was 100%. However,by comparison,average t!me of der- matitis occurrence in observation group was significantly delayed compared with control group（P〈0.05）. 90.0% of patients ap- peared dermatitis with grade 1,2 in observation group, while only 42.5% of patients in control group, level of RD in observauon group was generally lower than control group（P〈0.05）. The average healing time was （24.70±2.64）d in observation group and the average healing time of control group was （26.50 ± 2.64）d（P〈0.01）. Before radiotherapy, two groups of patients with KPS score and DLQI scores showed no significant difference （P〉0.05）. after radiotherapy, KPS scores in observation group were sig： nificantly higher than those in control group （P〈0. 01）, DLQI score was significantly lower than that of the control group （P〈0. 01）. Conclusion The ulcer oil of chinese herbs compound can significantly delay time of dermatitis occurrence, reduce grade of patient＇s dermatitis.accelerate the rate of healing, and improve the quality of life.

关 键 词：放射性皮炎 治疗结果 生活质量 溃疡油 

分 类 号：R730.55[医药卫生—肿瘤]