胆碱激酶α在肿瘤中的作用  

The role of choline kinaseαin tumorigenesis

作　　者：齐晨[1] 徐志飞[1] 

机构地区：[1]第二军医大学长征医院胸心外科,上海200003

出　　处：《第二军医大学学报》2016年第6期738-743,共6页Academic Journal of Second Military Medical University

基　　金：上海市科委基础研究重点项目(12JC1410900)~~

摘　　要：胆碱激酶α隶属于胆碱激酶蛋白家族,是CDP-胆碱通路的关键酶。在多种人类肿瘤组织中均发现有胆碱激酶α表达升高,如乳腺癌、结直肠癌、前列腺癌、肺癌等。研究已证实胆碱激酶α与多种肿瘤相关通路存在交互作用。由于其在肿瘤组织中的高表达和异常激活,胆碱激酶α可能是有助于肿瘤诊断的生物标记物,并有望成为肿瘤治疗的新靶点。本文从胆碱激酶α在肿瘤中的生物功能及其在肿瘤诊断及预后评估、肿瘤靶向治疗中的作用等方面综述了胆碱激酶α在肿瘤中的作用。Choline kinase a （CHOKa）, a member of the choline kinase family, is a key enzyme in the CDP-pathway. CHOKα has been reported overexpressed in a wide variety of human tumors including breast cancer, colorectal cancer, prostate cancer, and lung cancer. The interaction between CHOKa and cancer related pathways has been revealed. Due to its overexpression and aberrant activation in cancers, CHOKα is expected to be a potential biomarker and has been demonstrated to be a promising cancer therapeutic target. In this paper we reviewed the role of CHOKα in the tumorigenesis process, biological function, diagnosis and prognosis evaluation and tumor targeting therapy.

关 键 词：胆碱激酶α 肿瘤 生物功能 诊断 预后 治疗 

分 类 号：R73[医药卫生—肿瘤]