Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway  

作　　者：Yingxia Lan Yi Zou Tingting Huang Xiaozheng Wang Nelson L. Brock Zixin Deng Shuangjun Lin Yingxia Lan;Yi Zou;Tingting Huang;Xiaozheng Wang;Nelson L. Brock;Zixin Deng;Shuangjun Lin(State Key Laboratory of Microbial Metabolism:Joint International Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China)

机构地区：[1]State Key Laboratory of Microbial Metabolism:Joint International Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China

出　　处：《Science China Chemistry》2016年第9期1224-1228,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (NNSFC, 31425001 and 31070057 for SL);the Leopoldina Fellowship Program (German National Academy of Sciences Leopoldina, LPDS 2013-12 for NLB)

摘　　要：The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the ＂demethyl＂-maremycins with an unexpected D-tryptophan unit. A biosynthetic pathway for the maremycins is proposed and plausible reasoning for tryptopban epimerization in the demethylmaremycin biosynthesis is also provided.The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the"demethyl"-maremycins with an unexpected D-tryptophan unit. A biosynthetic pathway for the maremycins is proposed and plausible reasoning for tryptophan epimerization in the demethylmaremycin biosynthesis is also provided.

关 键 词：BIOSYNTHESIS maremycin N-METHYLATION METHYLTRANSFERASE EPIMERIZATION 

分 类 号：O621.3[理学—有机化学]