早期联合治疗H型高血压急性脑梗死临床效果观察  

Observation on clinical effect of early combined therapy in patients with H type hypertensive acute cerebral infarction

作　　者：康聚贤[1] 张培[1] 

机构地区：[1]河北医科大学附属邢台市人民医院,河北邢台054001

出　　处：《现代医药卫生》2016年第17期2641-2643,共3页Journal of Modern Medicine & Health

基　　金：河北省邢台市科技支撑计划项目(2014ZC155)

摘　　要：目的探讨尼莫地平联合叶酸对H型高血压(原发性高血压伴高同型半胱氨酸血症)急性脑梗死的疗效及预后的影响。方法将2014年12月至2015年8月该院收治的98例H型高血压急性脑梗死患者采用随机数字表法分为研究组(51例)和对照组(47例)。研究组给予尼莫地平40.0 mg(每天3次)及叶酸2.5 mg(每天1次),对照组给予尼莫地平40.0 mg(每天3次),其他用药两组基本相同。分别于治疗前,治疗后7、14、28 d测量患者血压、血浆同型半胱氨酸(Hcy)水平及Barthel指数评分。结果治疗后7 d两组患者血压、Barthel指数评分均优于治疗前,研究组患者血浆Hcy水平优于治疗前及对照组;治疗后14、28 d研究组患者血压、血浆Hcy水平及Barthel指数评分均优于对照组,差异均有统计学意义(P<0.05)。结论尼莫地平联合小剂量叶酸能有效控制H型高血压急性脑梗死患者的血压水平,降低血浆Hcy水平,改善脑梗死患者预后,且药物安全性高,经济性好,有利于提高患者依从性,适于基层医院临床推广应用。Objective To investigate the influence of nimodipine combined with folic acid on the therapeutic effect and prognosis in the patients with H type hypertensive acute cerebral infarction. Methods Ninety-eight patients with H type hypertensive acute cerebral infarction treated in our hospital from December 2014 to August 2015 were divided into the study group （51 cases ） and the control group （47 cases ） according to the random number table method. The study group was given nimodipine 40.0 mg （3 times daily） and folic acid 2.5 mg （once daily）, while the control group was given nimodipine 40.0 mg （3 times daily）, other medication was basically same in the two groups. The levels of blood pressure, plasma homocysteine （Hcy） and Barthel index scores were measured before treatment and on 7,14,28 d after treatment. Results The levels of blood pressure and Barthel in- dex scores on 7 d after treatment in the two groups were superior to those before treatment ,the plasma Hcy level in the study group was superior to that before treatment and in the control group;the levels of blood pressure,plasma Hcy level and Barthel index scores on 14,28 d after treatment in the study group were superior to those in the control group ,the differences were statistically significant（P〈0.05 ）. Conclusion Nimodipine combined with small dose of folic acid can effectively control the level of blood pressure, reduces plasma Hcy level and improves the prognosis in the patients with H type hypertensive acute cerebral infarction, moreover the medication safety is high with good economy ,which is conducive to increase the patient＇s compliance and suitable for the promotion and application in primary hospitals.

关 键 词：大脑梗死/药物疗法 急性病 尼莫地平/治疗应用 叶酸/治疗应用 H型高血压 

分 类 号：R743.33[医药卫生—神经病学与精神病学]