胃泌素释放肽前体和神经元特异性烯醇化酶对小细胞肺癌的诊断价值  

Diagnostic value of pro-gastrin-releasing peptide and neuron-specific enolase for small cell lung cancer

作　　者：朱金秀[1] 谢强[1] 钟爱虹[1] 卢筠[1] 廖胜祥[1] 臧焕平[1] 上官昌吉[2] 林清华[3] 

机构地区：[1]福建医科大学临床教学医院福州肺科医院肿瘤科,福建福州350008 [2]福建医科大学临床教学医院福州肺科医院检验科,福建福州350008 [3]福建医科大学临床教学医院福州肺科医院病理科,福建福州350008

出　　处：《现代医药卫生》2016年第17期2656-2657,共2页Journal of Modern Medicine & Health

摘　　要：目的探讨血清肿瘤标志物——胃泌素释放肽前体(Pro GRP)和神经特异性烯醇化酶(NSE)对小细胞肺癌(SCLC)的诊断价值。方法检测2014年6月至2015年7月该院收治的134例经病理检查确诊为SCLC患者(SCLC组)、126例非小细胞肺癌(NSCLC)患者(NSCLC组)、72例肺炎患者(肺炎组)、52例肺结核患者(肺结核组)血清Pro GRP及NSE水平,应用SAS9.0统计软件进行数据分析,组间比较采用Kruskal-Wallis H检验和Nemenyi法检验。结果 SCLC组患者血清Pro GRP、NSE水平均明显高于NSCLC组、肺炎组、肺结核组,差异均有统计学意义(P<0.01)。检测Pro GRP、NSE诊断SCLC的灵敏度分别为83.6%、91.0%,特异性分别为94.3、76.9%。二者联合检测诊断SCLC的灵敏度可提高至98.5%。结论检测肿瘤标志物——Pro GRP、NSE在SCLC的诊断中具有很重要的临床意义。Objective To evaluate the diagnostic values of pro-gastrin-releasing peptide （ProGRP）and neuron specific enolase （NSE）for small cell lung cancer （SCLC）. Methods Serum ProGRP and NSE levels were detected in our hospital from June 2014 to July 2015 in 134 cases of pathologically diagnosed SCLC （SCLC group ）, 126 cases of non small cell lung cancer （NSCLC group ）, 72 cases of pneumonia （pneumonia group ） and 54 cases of pulmonary TB. The obtained data were analyzed by using the SAS9.0 software. The inter-group comparison adopted Kruskal-Wallis H test and Nemenyi test. Results The levels of serum Pro-GRP and NSE in the SCLC group were significant higher than those in the NSCLC group,pneumonia group and pul monary TB group, the difference was statistically significant （P〈0.01 ）. The sensitivities of detecting ProGRP and NSE for diagnosing SCLC of were 83.5% and 91.0% respectively, the specificities were 94.3% and 76.9% respectively. The sensitivity of their combined detection could increase to 98.5%. Conclusion Detecting tumor marker ProGRP and NSE has a very important clinical significance in diagnosing SCLC.

关 键 词：癌 小细胞/诊断 肺肿瘤/诊断 胃泌素释放肽/诊断应用 

分 类 号：R743.33[医药卫生—神经病学与精神病学]