成人颅内神经母细胞瘤(1例报告并文献复习)  

Primary cerebral neuroblastoma in adults( a report of 1 case and review of literature )

作　　者：高进喜[1] 郑兆聪[1] 薛亮[1] 魏梁锋[1] 王守森[1] 

机构地区：[1]南京军区福州总医院神经外科,350025

出　　处：《临床神经外科杂志》2016年第3期226-228,共3页Journal of Clinical Neurosurgery

摘　　要：目的探讨原发性颅内神经母细胞瘤的临床、影像及病理学特点,以及治疗策略和预后。方法回顾性分析南京军区福州总医院神经外科收治的1例成人左侧额叶神经母细胞瘤患者的临床资料,将其临床、影像及病理学特点结合相关文献进行分析,并对患者进行跟踪随访。结果本例患者行神经导航下开颅肿瘤切除术,病理学检查证实为颅内神经母细胞瘤,术后以替莫唑胺同步放、化疗,后继以6周期辅助化疗。患者已无瘤生存4年,无明显神经功能缺失表现。结论成人颅内神经母细胞瘤极为少见且恶性程度高,手术完全切除肿瘤及术后正规放、化疗可显著提高患者的生存率。Objective To analyze the features of primary cerebral neuroblastoma in adults, and discuss the treatment protocols and prognosis of this disease. Methods The clinical features, radiological and pathologic images of a patient with primary left frontal lobe neuroblastoma were retrospectively analyzed. The follow up outcome was compared with the literatures. Results The patient underwent a total resection of tumor under navigation and microscope. Pathologic diagnosis confirmed the cellular cerebellar neuroblastoma. Chemotherapy with temozolomide and simultaneously radiotherapy followed surgical removal. The patient was in good condition and no relapse occurred for nearly 4 years. Conclusion The occurrence of primary cerebral neuroblastoma in adults is a high grade malignant tumor and distinctly rare. Our experience in this case suggest that complete resection followed by chemotherapy and radiotherapy may be the most effective means of the tumor control.

关 键 词：颅内神经母细胞瘤 神经影像学 病理学 替莫唑胺 

分 类 号：R739.41[医药卫生—肿瘤]