WHO Ⅲ级脑膜瘤的生存分析  

Survival analysis of World Health Organization grade Ⅲ meningiomas

作　　者：殷尚炯[1] 程月飞[1] 杜秀玉[1] 曹藏柱[1] 

机构地区：[1]解放军251医院神经外科,张家口市075000

出　　处：《临床神经外科杂志》2016年第4期255-258,共4页Journal of Clinical Neurosurgery

摘　　要：目的探讨WHOⅢ级脑膜瘤患者的预后影响因素。方法收集14例(男性4例,女性10例)经手术及病理诊断的WHOⅢ级脑膜瘤患者的临床及随访资料。应用Kaplan-Meier法和Cox回归模型对其性别、年龄、肿瘤部位、KPS评分、肿瘤切除程度,手术后放疗等临床特征进行单因素和多因素生存分析。结果本组14例患者的平均存活时间为60个月,中位生存时间为77个月,3年生存率为59%,5年生存率为51%,8年生存率为38%。12例大体全切的患者中平均复发时间为60个月,中位复发时间为43个月,3年复发率为55%,5年复发率为37%。单因素分析发现:性别(P=0.009)和手术切除程度(P=0.03)对WHOⅢ级脑膜瘤患者的生存时间有影响。Cox多因素预后分析未发现对生存时间和复发时间有影响的因素。结论手术全切是延长WHOⅢ级脑膜瘤患者生存期的重要因素。Objective To explore the outcomes and prognostic factors in patients with World Health Organization（WHO） gradeⅢmeningiomas.Methods The clinical and follow-up data of 14 patients （4 males and 10 females） with WHO grade III meningiomas diagnosed by surgery and pathology were analyzed retrospectively . Univariate and multivariate analysis were performed between gender, age, tumor location, Karnofsky Performance Status （KPS）,extent of resection, adjuvant radiology and survival time using Kaplan-Meier survival analysis and Cox proportional hazards models .Results Of 14 patients ,4 were male ,10 were female with a mean survival of 60 months and with a median survival of 77 months.3-year,5-year and 8-year overall survival （ OS） were 59%,51%and 38%respectively .Of 12 patients with surgical gross-total resection , there were a mean survival time of 60 months and with a median survival time of 43 months.3-year,5-year recurrence-free survival （ RFS ） were 55% and 37% respectively .Univariate analysis showed the gender（P=0.009） and surgical extent of resection（P=0.03） have statistically significant effect on OS.All factors were not found statistically significant effect on OS and RFS by Cox proportional hazards models .Conclusions Gross-total resection were key means to prolong survival time of patients with World Health Organization grade Ⅲmeningiomas.

关 键 词：恶性脑膜瘤 生存分析 手术切除 放疗 

分 类 号：R739.45[医药卫生—肿瘤]