功能性消化不良患者躯体化与抑郁关系的研究  

Research on the correlation between somatisation and depression in patients with functional dyspepsia

作　　者：明文[1] 张红[1] 贺国斌[1] 向军英[1] 李群华[1] 刘倩[1] 

机构地区：[1]川北医学院附属医院消化内科,四川南充637000

出　　处：《临床内科杂志》2016年第8期545-548,共4页Journal of Clinical Internal Medicine

基　　金：川北医学院附属医院院级课题项目（2015076）

摘　　要：目的探讨功能性消化不良（FD）患者躯体化与抑郁的相关性。方法对279例FD患者行健康问卷躯体症状群量表（PRQ-15）及汉密尔顿抑郁量表（HAMD17）调查，统计分析抑郁与躯体化的分布、关系及具体躯体化症状对抑郁的影响。结果FD患者抑郁状态发生率为41．2％，躯体化症状发生率为54．8％；FD、上腹痛综合征（EPS）、餐后不适综合征（PDS）、重叠组躯体化与抑郁皆呈正相关（r=0．546，P=0．000；r=0．564，P=0．000；r=0．437，P=0．002；r=0．628，P=0．000）；线性回归分析发现四肢或关节痛、头痛、胸痛、头晕、气促、恶心、胀气或消化不良、感到疲乏是影响抑郁较为明显的因素（β=0．226，P=0．032；β=0．285，P=0．011；β=0．011，P=0．000；β=0．280，P=0．024；β=0．563，P=0．000；β=0．453，P=0．001；β=0．322，P=0．002）。结论FD患者的躯体化症状及抑郁状态常见，二者之间具有显著相关性，临床工作中重视这些症状及抑郁对FD的影响对总体治疗有益。Objective To explore the correlation between somatic symptoms and depression in patients with functional dyspepsia（FD）. Methods 279 consecutive outpatients with FD were enrolled to finish the Patient Health Questionnaire-15 （ PHQ-15 ） and Hamilton depression scale-17 （ HAMD-17 ）. Analyze the distribution of depression and somatisation and their relationship, and the effects of each somatic symptom on depression. Results The incidences of depression and somatic symptoms in FD patients were approximately 41.2% and 54.8 % respectively. Somatisation in FD （r = 0. 546,P = 0.000 ）, Epigastric pain syndrome （ EPS ） （ r = 0. 564, P = 0. 000 ）, Postprandial distress syndrome （ PDS ） （ r = 0. 437,P = 0. 002） and overlap group （ r = 0. 628, P = 0. 000 ） were positively correlated with depression. Pain in arms, legs, or joints （β= 0. 226, P = 0. 032 ） , headaches （/3 = 0. 285, P = 0.011 ） , chest pain （β = 0.011, P = 0. 000 ）, dizziness （β = 0. 280, P = 0. 024 ）, shortness of breath （β = 0. 563, P = 0. 000 ）, nausea, gas, or indigestion （β = 0. 453, P = 0. 001 ）, feeling tired （β= 0. 322, P = 0. 002 ） were distinctly associated with depression by multiple linear regression analysis （ P 〈 0. 05 ）. Conclusion Somatic symptoms and depression are common and have a significant relationship in FD patients. Pay attention to these results to the treatment of FD may be beneficial.

关 键 词：功能性消化不良 躯体化 抑郁 

分 类 号：R743.3[医药卫生—神经病学与精神病学]