CEA、Ca125、Ca199和SCC检测在宫颈癌和癌前病变诊断中的应用价值  

Significances of CEA,Ca125,Ca199 and SCC in Cervical Cancer and Cervical Precancerous Lesion

作　　者：沈慧[1] 左绪磊[1] 

机构地区：[1]复旦大学附属金山医院,上海201508

出　　处：《中国初级卫生保健》2016年第9期34-36,共3页Chinese Primary Health Care

摘　　要：目的探讨癌胚抗原(CEA)、鳞状细胞癌抗原(SCC)、血清糖类抗原125(Ca125)和糖链抗原199(Ca199)在宫颈癌和癌前病变诊断中的临床意义。方法检测宫颈癌、宫颈上皮内瘤变(CIN)患者和健康女性的CEA、SCC、Ca125和Ca199水平并进行比较分析。结果宫颈癌组患者CEA、SCC、Ca125和Ca199水平均明显高于CIN组和对照组(P<0.05),CIN组患者SCC水平明显高于对照组;临床分期越高、肿瘤≥4 cm和分化程度越低,宫颈癌患者SCC水平越高;肿瘤≥4 cm,Ca199水平越高;宫颈腺癌患者的Ca125、Ca199水平明显高于宫颈鳞癌患者,宫颈鳞癌患者的SCC水平明显高于宫颈腺癌患者。结论综合分析CEA、SCC、Ca125和Ca199水平可以对宫颈癌和癌前病变做到早发现、早诊断和早治疗,并可进行病情评估,改善预后。OBJECTIVE To study the significances of CEA, Ca125, Ca199 and SCC in cervical cancer and cervical precancerous lesion. METHODS To test and compare the levels of Ca199, Ca125, SCC and CEA in patients with cervical cancer, cervical precancerous lesion（CIN） and healthy controls. RESULTS The levels of Ca199, Ca125, SCC and CEA in cervical cancer group were significantly higher than those in CIN group and control group（P〈0.05）, the level of SCC in CIN group was significantly higher than control group; the higher clinical stage was, tumor size ≥4 cm, the lower the degree of differentiation would be. The higher the level of SCC in patients with cervical cancer was the tumor size ≥4 cm, the higher the Ca199 level was; the level of Ca125 and Ca199 in patients with cervical adenocarcinoma was significantly higher than that in patients with squamous cell carcinoma. The level of SCC in cervical squamous cell carcinoma was significantly higher than that in patients with cervical carcinoma. CONCLUSION Ca199, Ca125, SCC and CEA could be used to diagnose and treat cervical cancer and precancerous lesions.

关 键 词：肿瘤标志物 宫颈癌 癌前病变 检测 

分 类 号：R737.33[医药卫生—肿瘤]