胎盘多肽注射液联合放化疗治疗中晚期鼻咽癌的疗效观察  

Curative effect observation of placenta polypeptide injection combined with radiotherapy and chemotherapy in advanced nasopharyngeal carcinoma

作　　者：于瑞莲[1] 安宁[1] 兰海涛[1] 李宏敏[1] 

机构地区：[1]四川省医学科学院.四川省人民医院肿瘤科,四川成都610072

出　　处：《西部医学》2016年第9期1227-1229,1233,共4页Medical Journal of West China

基　　金：四川省科技支撑计划项目(2015S2087)

摘　　要：目的观察胎盘多肽注射液联合放化疗治疗中晚期鼻咽癌的近期疗效和不良反应。方法将56例中晚期鼻咽癌患者随机分为治疗组28例和对照组28例,两组患者均接受调强适形放射治疗(intensity modulated radiation therapy,IMRT),同时予顺铂同步化疗,40mg/m2,每周1次,治疗组在此基础上加用胎盘多肽注射液辅助治疗。比较两组患者近期疗效和不良反应。结果两组患者均完成同步放化疗,两组总有效率无明显差异(P>0.05);但治疗组患者体力状况评分较对照组明显改善,差异有统计学意义(2=5.203,P=0.023)。治疗组Ⅲ/Ⅳ度白细胞减少发生率明显低于对照组(P<0.05);口腔黏膜炎及放射性皮肤反应发生率均明显低于对照组(P<0.05)。结论胎盘多肽注射液联合同步放化疗治疗中晚期鼻咽癌有一定的辅助作用,能改善患者的体力状态,减轻或降低同步放化疗引起的毒副作用,无明显不良反应,值得临床进一步推广应用。Objective To observe the short term efficacy and adverse reaction of placenta polypeptide injection combined with radiotherapy and chemotherapy in treatment of advanced nasopharyngeal carcinoma. Methods 56 patients with advanced nasopharyngeal carcinoma were randomly divided into treatment group （28 cases） and control group （28 cases）. The two groups were treated with intensity modulated radiation therapy （IMRT）, concurrent chemotherapy, 40mg/m2 , once a week. On the basis of the treatment, the treatment group was treated with placenta polypeptide injec- tion. The short-term efficacy and adverse reactions of the two groups were compared. Results The patients in the two groups were all completed concurrent radiotherapy and chemotherapy. The total effective rate of the two groups had no significant difference. The patients in the treatment group physical status score improved significantly compared with the control group. The difference was statistically significant （X2=5. 203 ,P=0. 023）. The incidence of grade III/ IV bone marrow suppression in treatment group was significantly lower than that in control group （P〈0.05）. The incidence rate of oral mucosal inflammation and radioactive skin reaction in treatment group was significantly lower than that in control group （P〈0.05）. Conclusion Placenta polypeptide injection combined with radiotherapy and chemotherapy in treatment of advanced nasopharyngeal carcinoma has a supporting role, which can improve the physical status of the patients, alleviate or reduce the toxic effect of concurrent chemoradiotherapy and has no obvious adverse reactions.

关 键 词：胎盘多肽注射液 鼻咽癌 同步放化疗 

分 类 号：R739.62[医药卫生—肿瘤]