异甘草酸镁治疗慢性肝病临床疗效及对实验室指标改善的影响  

Clinical curative effect of magnesium isoglycyrrhizinate in treatment of chronic liver disease and its influence on improvement of laboratory indexes

作　　者：王友春[1] 

机构地区：[1]河南省洛阳市中心医院,河南洛阳471000

出　　处：《中国医药科学》2016年第15期82-84,115,共4页China Medicine And Pharmacy

摘　　要：目的探讨慢性肝病（CLD）应用异甘草酸镁（MgIG）治疗的临床效果及其对患者实验室指标的影响。方法选取我院2015年1月。2016年3月收治的118例CLD患者，随机等分为两组。对照组在常规综合治疗基础上，给予常规护肝药物治疗；观察组在常规综合治疗基础上，联合MgIG治疗。记录比较两组临床疗效，治疗前后血清前白蛋白（PA）、总胆红素（TBIL）、谷丙转氨酶（ALT）及谷草转氨酶（AST）水平，治疗期间药物不良反应。结果观察组总有效率为94．92％，明显高于对照组的81．36％（P〈0．05）；与治疗前比较，治疗后两组PA、TBIL、ALT及AST水平均显著改善（P〈0．01），且观察组改善程度更为显著（P〈0．01）；观察组不良反应率为6．78％与对照组20．34％相比，明显更低（P〈0．05）。结论CLD应用MgIG治疗临床疗效切实，更有利于改善肝功能，副作用小，具有较高临床参考价值。Objective To explore the clinical effects of magnesium isoglycyrrhizinate （MglG） in the treatment of chronic liver disease （CLD） and its influence on laboratory indexes. Methods 118 cases of CLD patients treated in our hospital from January 2015 to March 2016 were selected and randomly divided into two groups. On the basis of routine comprehensive treatment, patients in the control group were given conventional liver drugs. On the basis of conventional comprehensive treatment, patients in the observation group were treated with MgIG treatment. Clinical curative effects, levels of serum prealbumin （PA）, total bilirubin （TBIL）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） before and after the treatment and adverse reactions of drugs during the period of treatment of the two groups were recorded and compared. Results The total effective rate of the observation group was 94.92%, which was significantly higher than that of the control group with 81.36% （P 〈 0.05）. Compared with those before the treatment, levels of PA, TBIL, ALT and AST in the two groups were improved significantly after the treatment （P 〈 0.01）, and the improvement degree of the observation group was more significant （P 〈 0.01）. The adverse reaction rate of the observation group was 6.78%, which was significantly lower than that of the control group with 20.34% （P 〈 0.05）. Conclusion The application of MgIG in the treatment of CLD has accurate clinical effects and is more conducive to improve liver function with small side effects, which has a high clinical reference value.

关 键 词：异甘草酸镁 慢性肝病 实验室指标 

分 类 号：R575[医药卫生—消化系统]