低氧条件下低氧诱导因子1α/miR-210调节回路对肿瘤能量代谢及血管生成的调控  

Regulation of HIF-1α/miR-210 loop on energy metabolism and angiogenesis in hypoxic condition

作　　者：曹治云[1] 张志灯[2] 陈旭征[1] 黄争荣[3] 王雷[4] 陈立武[5] 陈瑞琦[6] 廖联明[7] 

机构地区：[1]福建中医药大学中西医结合研究院,福州350122 [2]福建出入境检验检疫局检验检疫技术中心,福州350003 [3]福建省肿瘤医院中西医结合科,福州350014 [4]上海市第一人民医院肿瘤科,200080 [5]福建省第二人民医院普外科,福州350003 [6]南京军区福州总医院476临床部药剂科,福州351100 [7]福建医科大学附属协和医院,福州350004

出　　处：《中华细胞与干细胞杂志（电子版）》2016年第3期195-198,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然基金项目(81302954)

摘　　要：低氧诱导因子1(HIF-1)是低氧下肿瘤细胞信号通路的核心调控因子,研究表明与HIF-1生物学调控功能(血管生成、能量代谢、细胞增殖、细胞凋亡和侵袭转移等)起协同作用的是mi R-210,mi R-210受低氧及HIF-1α调控而表达上调,反之上调的mi R-210又增强HIF-1α分子稳定性,由此两者共同构成HIF-1α/mi R-210调节回路,对肿瘤细胞多种生物学行为进行精确调控,本文对HIF-1α/mi R-210调节肿瘤能量代谢及血管生成两方面做一简要综述。HIF-1 is a core regulatory factor in hypoxic signaling pathways of tumor. Studies show that miR-210 plays a synergistic role in the HIF-1-mediated biological activities including angiogenesis, energy metabolism, cell proliferation, apoptosis, invasion and metastasis. In hypoxia miR-210 is up-regulated by HIF-1α and miR-210 in turn enhances the stability of HIF-1α, thus the two together constitute the HIF-1α/miR-210 regulation loop and regulate various biological behaviors of tumor cells. In this review, we focus on the regulation of tumor energy metabolism and angiogenesis by HIF-1 /miR-210.

关 键 词：芳香烃受体核转位子 微RNAs 能量代谢 血管生成 

分 类 号：R730.2[医药卫生—肿瘤]