云南宣威非小细胞肺癌（NSCLC）中水通道蛋白1（AQP1）的表达及意义  

作　　者：雷常成[1] 展希[1] 太祥[1] 洪志鹏[1] 

机构地区：[1]云南昆明医学院第一附属医院胸外科,昆明650031

出　　处：《世界中医药》2016年第B03期834-835,共2页World Chinese Medicine

摘　　要：目的 通过检测云南宣威地区NSCLC中AQP1的表达，分析AQP1与云南宣威地区NSCLC在生长、转移、侵袭等之间关系。方法：取昆明医科大学第一附属医院云南宣威地区肺腺癌患者用免疫组化方法（SP法）检测NSCLC中AQP1的表达，分析其与年龄、性别、分化程度、TNM分期和有否淋巴结转移之间的关系。结果：NSCLC中AQP1的表达明显高于正常肺组织中AQP1。检测分析得出NSCLC与年龄、性别、TNM分期无关（P〉0．05），而与分化程度呈负相关，与有否淋巴结转移呈正相关（P〈0．05）。结论：云南宣威地区NSCLC中AQP1的高表达与肺癌的侵袭转移密切相关．为该地区以后的研究提供了依据。Objective Through testing the expression of AQP1 of Xuanwei area NSCLC of Yunnan. To analyze relationshipamong growth, transfer and invasion between AQP1 and NSCLC of Yunnan Xuanwei area. Methods： To take 27 eases ofXuanwei lung adenocarcinoma at the first affiliated hospital of Kunming medical university , 25 cases of lung squamous cellcarcinoma, 19 cases of normal lung tissue . Using immunohistochemical method （SP method） to test the expression of AQP1 inNSCLC, we analyze it and the relationship among the age, sex, differentiation degree, TNM staging and the lymph nodemetastasis. Results： The expression of AQPI in NSCLC is significantly higher than that of normal lung tissue, through testanalysis that NSCLC is irrelevant with age, sex and TNM staging （P 〉 0.05）; NSCLC have a negative correlation withdifferentiation degree; NSCLC have a positive correlation with lymph node metastasis （P 〈 0.05）. Conclusion： there is aeloser relationship between the higher expression of AQP1 in NSCLC of Yunnan Xuanwei area and invasion and metastasis oflung cancer, which provides a basis for later research there.

关 键 词：云南宣威 水通道蛋白1 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]