电针干预肾精亏虚型轻度认知功能障碍的1H-MRS研究  

作　　者：刘洁[1] 宋跌星 朱玉新[1] 刘智艳 姜迎萍 

机构地区：[1]新疆阿克苏职业技术学院医学系,新疆阿克苏843000 [2]新疆自治区中医医院,新疆乌鲁木齐830000

出　　处：《世界中医药》2016年第B03期1093-1095,共3页World Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金项目资助（项目编号：2009211A22）.

摘　　要：目的使用zH-MRS观察电针对轻度认知功能障碍患者的干预效应，客观评价此法的临床疗效。方法：选择32例肾精亏虚型轻度认知功能障碍患者，随机分为2组。电针组采用补肾填髓针刺法并接电针；对照组采用口服盐酸多奈哌齐片剂，10d为一个疗程，三个疗程后观察疗效。结果：神经心理学量表评分：电针组治疗前后MMSE和CMS得分比较具有显著性差异（P〈0．05），而对照组无明显差异（P〉0．05）。磁共振波谱测定：在右侧颞尖，对照组治疗前后NAA／Cr降低（P（0，05），而电针组治疗前后NAA／Cr无明显变化，且2组间差异有统计学意义（P〈0．05）；在左侧海马，电针组治疗前后NAA／Cr升高（P〈0．05），而对照组无明显差异（P〉O．05），且与对照组比较差异有统计学意义（P〈0．05）；在左侧颞尖，电针组治疗前后MI／Cr降低（P〈0．05），而对照组无明显差异（P〉0．05），且2组间差异有统计学意义（P（0．05）。结论：电针可通过延缓脑内代谢物NAA的降低、提高NAA含量、减少脑内代谢物MI的含量，来达到减少神经胶质的生成，修复神经元，改善认知功能的作用。Objective 1H-MRS to observe the use of electricity for patients with mild cognitive impairment cognitive intervention effect, and objectively evaluate the clinical efficacy of this method.Methods：Thirty-two cases patients with mild cognitive impairment, were randomly divided into two groups. Electro-acupuncture group ways to use the tonify the kindney myeloid fill and then connected electric-acupuncture; The control group using Donepezil Hydrochloride oral tablets in 10 days for a treatment effect observed after three treatments. Results： Electro- acupuncture group and the CMS before and after treatment MMSE score compared with a significant difference （P〈0.05）, while no significant difference between the control group （P〉0.05）. At the right temporal tip, the control group before and after treatment in NAA/Cr reduced （P〈 0.05）, and electro-acupuncture treatment before and after the NAA/Cr had no significant change （P〉0.05）, and the difference between the two groups there is significant（P〈0.05）;In the left hippocampus, electro-acupuncture group before and after treatment NAA/Cr increased （P〈0.05）, the control group no significant difference （P〉0.05）, and compared with the control group were statistically significant differences（P〈0.05）;In the left temporal tip, electro-acupuncture group after treatment than before treatment MYCr reduced （P〈0.05）, the control group no significant difference （P〉0.05）, and the difference between the two groups has statistical significance （P〈0.05）. Conclusion： Electric acupuncture may be reduced by slowing down the brain metabolites of NAA, improve the NAA content; reduce the content of brain metabolites MI, to reduce the formation of glia, repair neurons, improve cognitive function.

关 键 词：电针 轻度认知功能障碍 氢质子磁共振波谱 

分 类 号：R749[医药卫生—神经病学与精神病学]