17例甲状腺髓样癌的针吸细胞学形态分析  

Value of fine needle aspiration biopsies in the diagnosis of medullary thyroid carcinoma： Analysis of 17 cases

作　　者：张学东[1] 陈士超[2] 杜颖[1] 任玉波[1] 

机构地区：[1]聊城市人民医院病理科,252000 [2]聊城市人民医院急诊内科,252000

出　　处：《中华内分泌代谢杂志》2016年第8期677-679,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：分析17例经组织学证实的MTC细针穿刺标本，总结其细胞形态学特征。17例MTC细胞学涂片表现有以下形态特点：（1）细胞量均中等～丰富；（2）细胞排列以分散细胞和成簇细胞混杂为主；（3）细胞形态浆细胞样（圆形、卵圆，胞核偏位）和（或）短桫梭形；（4）细胞轻～中等多形性，形态相对一致，偶见个别稍大细胞；（5）双核细胞多见，偶见巨核细胞；（6）细胞核染色质以椒盐状，个别病例细腻；（7）核内假包涵体并不常见；（8）无明显核仁；（9）细胞质较少，个别病例胞质丰富；（10）可见淀粉样物质；（11）未见核分裂像。掌握这些细胞学特点MTC就能用FNA确诊，结合临床信息及细胞块免疫组化可提高MTC诊断的准确性。The cytomorphological features of 17 cases of confirmed MTC were analyzed, cytomorphological features were moderate to marked cellularity, isolated cells alternate with clusters in variable proportions, plasmacytoid, polygonal, round, and （or）spindle-shaped cells, mild to moderate pleomorphism, finely or salt and pepper-like chromatin, frequent binucleationfmultinuleation, rare bizarre giant cells may be seen, nuclear pseudoinclusions are occasionally noted, unremarkable nucleoli, cytoplasm is granular and variable. Amyloid is often present. MTC could be adequately diagnosed by FNA, According to the clinical characteristics and cellblock immunochemical staining can be helpful in diagnosis of MTC.

关 键 词：甲状腺肿瘤 针吸细胞学 甲状腺髓样癌 

分 类 号：R736.1[医药卫生—肿瘤]