老年高血压脑出血患者应用复方麝香注射液配合血肿微创引流的效果及预后研究  

Effect and Prognosis of Application in Elderly Hypertensive Intracerebral Hemorrhage by Compound Musk Injection with Hematoma Drainage

作　　者：谢强[1] 王飞[1] 张慧[1] 

机构地区：[1]南阳市中心医院,河南南阳473000

出　　处：《中华中医药学刊》2016年第9期2228-2231,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省自然科学基金项目(0511041900)

摘　　要：目的:探讨老年高血压脑出血患者应用复方麝香注射液配合血肿微创引流的效果及其预后研究。方法:选择2013年6月—2014年9月在医院收治的确诊中老年高血压脑出血患者70例,随机分为观察组和对照组,每组35例。两组患者均采用止血、脱水、防治感染等常规治疗手段,并进行颅骨锥孔脑血肿引流术。观察组患者在手术治疗的基础上,每天静脉滴注复方麝香注射液。治疗结束后,对患者的生命体征、瞳孔、意识等一般临床症状进行评价。结果在治疗后1、2、3周,观察组患者血肿、水肿及NIHSS功能评定的测定结果低于对照组;观察组患者在术后1、3个月的神经功能缺损评分显著低于对照组;观察组患者治疗后4周的FAM评分明显低于对照组;在治疗后3个月,观察组缺损程度良好-中残率(71.5%)和重度残疾(28.5%)明显低于对照组;观察组治疗的总有效率(94.3%)显著大于对照组(77.1%);以上差异有统计学意义(P<0.05)。结论:复方麝香注射液配合血肿微创引流术治疗中老年高血压脑出血患者,比单纯的手术治疗效果明显,能降低并发症和致残率,改善患者的生活质量,值得临床进一步推广、研究。Objective ：To explore the effect and prognosis of application in elderly hypertensive intracerebral hemor- rhage by Compound Musk Injection with hematoma drainage. Methods：Seventy patients diagnosed aselderly hypertensive intracerebral hemorrhage in our hospital were selected from June 2013 to September 2014and randomly divided into obser- vation group and control group,35 cases in each group. Two groups were treated with the prevention and control of bleed- ing, dehydration, anti - infection and other conventional treatmentand also treated by the skull taper brain hematoma drain- age. Observation group＇s patients were treated by daily intravenous infusion of Compound Musk Injection, on the basis of operative treatment. After all treatments, the general clinical symptoms of patients were evaluated, such as vital signs, pu- pil,consciousness. Results：The hematoma, edema and NIHSS function evaluation of observation group were lower than those of the control group after treatment of 1,2 and 3 weeks. The neurological deficit scores of patients in observation group were significantly lower than the control group＇ s at 1 and 3 months after surgery. Patients＇ FAMI score in observa- tion was significantly lower than the control group＇ s after 4 weeks treatment. After 3 months of treatment, the disability rate （71.5%） and severe disability （28.5%） in observation group were significantly lower than the control group＇s. The total effective rate in observation group （94.3%） was higher than the control group＇s （77.31%）. The above difference was statistically significant （P 〈0.05 ）. Conclusion：The effect of Compound Musk Injection combined with minimally in- vasive hematoma drainage in the treatment of hypertension in elderly patients with cerebral hemorrhage is significantly higher than that of the simple surgery,which can reduce complications and disability,improve patients＇ quality of lifeand is worthy of further promotion and research.

关 键 词：高血压 复方麝香注射液 血肿微创引流 

分 类 号：R743.34[医药卫生—神经病学与精神病学]