儿童抽动障碍患儿病毒与细菌感染血清中IL-6和TNF-α水平变化的分析  

Changes of levels of serum IL-6 and TNF-α in dic disorder children with viral and bacterial infections

作　　者：程德君[1] 张桂艳[2] 王娟[1] 孙臻[1] 冯砚国[1] 

机构地区：[1]河南省精神病院.新乡医学院第二附属医院精神一科,河南新乡453002 [2]河南省精神病院.新乡医学院第二附属医院功能检查科,河南新乡453002

出　　处：《中华医院感染学杂志》2016年第17期4070-4072,共3页Chinese Journal of Nosocomiology

基　　金：河南科技厅基金资助项目(XP201501114)

摘　　要：目的探讨儿童抽动障碍患儿病毒与细菌感染后患儿血清中白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)等相关炎性细胞因子水平的变化,为临床诊治提供参考和借鉴。方法选取2013年12月-2014年10月医院收治的儿童抽动障碍患儿52例为研究组,同时选取同期来院体检的健康儿童52例为对照组,对两组儿童的病毒与细菌感染情况、炎性细胞因子水平和T淋巴细胞亚群指标等进行观察比较。结果研究组患儿的病毒感染率23.08%、细菌感染率28.85%、总感染率51.92%;研究组患儿的IL-1、IL-6、IL-8和TNF-α等各项炎性细胞因子水平分别为(128.34±65.93)pg/ml、(318.23±183.04)pg/ml、(87.53±32.04)pg/ml和(187.34±38.98)pg/ml,高于对照组的(8.91±1.53)pg/ml、(7.82±4.32)pg/ml、(1.53±0.34)pg/ml和(12.98±3.21)pg/ml;研究组的CD4+水平为(34.09±4.32)%低于对照组的(40.92±2.83)%,研究组的CD8+水平为(36.98±2.94)%高于对照组的(30.28±6.24)%,差异均有统计学意义(P<0.05)。结论儿童抽动障碍患儿的病毒与细菌感染水平较高,患儿血清IL-6和TNF-α等炎性细胞因子水平升高,T淋巴细胞亚群水平会出现异常。OBJECTIVE To explore the changes of levels of inflammatory cytokines such as serum interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）in dic disorder children with viral and bacterial infections so as to provide guidance for clinical diagnosis and treatment.METHODS Totally 52 children with dic disorder who were treated in the hospital from Dec 2013 to Oct 2014 were chosen as the study group,meanwhile,52 healthy children who received physical examination were set as the control group.The incidence of viral,bacterial infections,levels of inflammatory cytokines,and T lymphocyte subsets were observed and compared between the two groups of children.RESULTS The incidence of viral infections was 23.08%in the study group,the incidence of bacterial infections was 28.85%,and the total infection rate was 5.77%.The level of IL-1of the study group was（128.34±65.93）pg/ml,higher than（8.91±1.53）pg/ml of the control group;the level of IL-6of the study group was（318.23±183.04）pg/ml,higher than（7.82±4.32）pg/ml of the control group;the level of IL-8of the study group was（87.53±32.04）pg/ml,higher than（1.53±0.34）pg/ml of the control group;the level of TNF-αof the study group was（187.34±38.98）pg/ml,higher than（12.98±3.21）pg/ml of the control group.The level of CD4^＋of the study group was（34.09±4.32）%,lower than（40.92±2.83）% of the control group;the level of CD8^＋of the study group was（36.98±2.94）%,higher than（30.28±6.24）% of the control group（P〈0.05）.CONCLUSIONThe incidence of viral,bacterial infections is relatively high in the children with tic disorder,the levels of the inflammatory cytokines such as IL-6and TNF-αare elevated,and the levels of T lymphocyte subsets show abnormal.

关 键 词：儿童抽动障碍 白介素-6 肿瘤坏死因子-Α 

分 类 号：R748[医药卫生—神经病学与精神病学]