光学纯3-羟基丁酸乙酯制备技术研究进展  

Research Progress in Preparation Technique of Enantiomeric Pure Ethyl-3-hydroxybutyrate

作　　者：侯静[1] 孙婧[1] 何军邀[2] 黄金[1] 王普[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]浙江医药高等专科学校,浙江宁波315100

出　　处：《浙江化工》2016年第8期25-29,共5页Zhejiang Chemical Industry

基　　金：浙江省新苗计划项目(2015R403073);浙江省公益性项目(No.2015C33137);浙江省自然科学基金(LY16B060010)

摘　　要：光学纯3-羟基丁酸乙酯(EHB)是具有广泛应用价值的手性中间体,目前有多种制备方法。主要综述了手性3-羟基丁酸乙酯的合成和拆分制备研究进展,概述相关的手性拆分,不对称合成制备方法,重点介绍了生物不对称合成法制备技术的研究现状。Enantiomeric pure ethyl-3-hydroxybutyrate is a versatile and valuable chiral intermediate in pharmaceutical industry. Several preparation methods have been reported so far. In this paper, research process on the production of enantiomeric pure ethyl-3-hydroxybutyrate was summarized, including chiral resolution and asymmetric synthesis, especially the asymmetrically biocatalytic synthesis of optically active ethyl-3-hydroxybutyrate.

关 键 词：光学纯3-羟基丁酸乙酯 手性中间体 拆分 不对称合成 

分 类 号：TQ225.4[化学工程—有机化工]