^(18)F-FDG PET/CT显像半定量参数MTV、TLG联合SUV在乳腺癌诊断中的应用价值  

Clinical value of ^(18)F-FDG uptake, described by metabolic tumor volume, total lesion glycolysis and standard uptake values in breast cancer

作　　者：张倩[1] 辛军[1] 李红 

机构地区：[1]中国医科大学附属盛京医院核医学科,辽宁沈阳110004 [2]通用电气医疗系统贸易发展(上海)有限公司,辽宁沈阳110003

出　　处：《中国临床医学影像杂志》2016年第9期620-624,共5页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨应用^(18)F-FDG PET/CT显像MTV、TLG、SUVmax、SUVmean及SUVpeak对乳腺癌的诊断价值。资料与方法:回顾性分析2011年12月—2015年8月我院确诊为乳腺癌的患者48例,术前行^(18)F-FDG PET/CT检查,通过测定MTV、TLG及SUVmax、SUVpeak及SUVmean,采用t检验、单因素方差分析及Spearman相关性分析,评价上述代谢指标同乳腺癌原发灶大小、转移情况及病理免疫组化及相关受体之间的关系。结果:较高T级别肿瘤各代谢指标值较高,各代谢指标在T2~T4与T0~T1级别两者中差异均具有统计学意义(P<0.05),有淋巴结或脏器转移(N1~N3及M1)的癌灶的各代谢值高于无转移(N0及M0)肿瘤,其中MTV及TLG值显著,具有统计学意义(P<0.05),Ki67及p53指数与各代谢值均无相关性,但Ki67高表达肿瘤较之低表达者代谢水平较高,差异无统计学意义(P>0.05),各代谢指标值与乳腺癌相关受体ER、PR及HER-2的表达与否差异无统计学意义。结论:5者的组合能比较全面评估乳腺癌恶性程度及侵袭力,MTV及TLG是其中较好的指标。Objective： The aim of this study was to observe the value of different metabolic parameters（MTV, TLG, SUVmax, SUVmean and SUVpeak） in breast cancer. Materials and Methods： Forty-eight patients of breast cancer underwent PET/CT imaging before operation consecutively from December 2011 to August 2015, maximum, peak and mean standardized uptake values（SUVmax, SUVpeak and SUVmean）, metabolic tumor volume（MTV） and total lesion glycolysis（TLG） in the primary tumor were calculated and compared with sizes, metastatic situation, immunohistoehemical characterization and oestrogen receptor（ER）, progesterone receptor （PR）, HER-2 status, being analyzed with T-text, ANOVA, spearman analysis. Results： Most of metabolic parameters were higher in high T-grade lesions, significant correlation was found between all metabolic parameters in T2-T4 and T0-T1, all the parameters were higher in M1/N1-N3 than lesions compared with M0/N0, significant correlation was found only for TLG and MTV（P〈0.05）. TLG and MTV were higher in the cancers with Ki67 ≥ 14%, however there was no correlation between the Ki67 or p53 expression and all the parameters. No significant correlation was found between all metabolic parameters and ER, PR or HER-2 status. Conclusion： Metabolic tumor volume, total lesion glycolysis and SUV combined detection can be used as an evaluation index for judging the malignant degree and invasiveness, MTV and TLG are the better index.

关 键 词：乳腺肿瘤 正电子发射断层显像术 体层摄影术 螺旋计算机 

分 类 号：R737.9[医药卫生—肿瘤] R817.4[医药卫生—临床医学]