超低频重复经颅磁刺激与帕罗西汀治疗老年抑郁症对照研究  

A control study of ULF-rTMS and paroxetine in the treatment of senile depression

作　　者：庞润慧 何莉萍[1] 马元业 魏长礼 

机构地区：[1]天水市第三人民医院,甘肃·天水741000

出　　处：《临床心身疾病杂志》2016年第5期14-16,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨超低频重复经颅磁刺激与帕罗西汀治疗老年抑郁症的临床疗效及安全性。方法将65例老年抑郁症患者采用随机数字表法分为两组，研究组给予超低频重复经颅磁刺激治疗，对照组口服帕罗西汀治疗，观察6周。于治疗前后采用汉密顿焦虑量表、汉密顿抑郁量表及临床疗效总评量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组汉密顿焦虑量表与汉密顿抑郁量表评分均较治疗前显著下降（P〈0．05或0．01），治疗1周末研究组各量表评分显著低于对照组（P〈0．05），其他时点评分两组比较差异无显著性（P〉0．05）；治疗6周末研究组总有效率为78．8％，对照组为81．3％，两组比较差异无显著性（P〉0．05）。治疗后两组临床疗效总评量表评分均较治疗前显著降低（P〈0．05或0．01），同期两组间评分比较差异均无显著性（P〉0．05）。研究组不良反应发生率为12．10．4，对照组为34．4％，研究组不良反应发生率显著低于对照组（P〈0．05）。结论超低频重复经颅磁刺激治疗老年抑郁症起效快，疗效显著且与帕罗西汀相当，安全性高。Objective To explore the efficacy and safety of ultra-low frequency repetitive transcranial magnetic stimulation （ULF-rTMS） and paroxetine in the treatment of senile depression. Methods Sixth-five senile depression patients were randomly assigned to two groups, research group received ULF-rTMS, and control group took orally paroxetine for 6 weeks. Efficacies were assessed with Hamilton Anxiety Scale （HAMA）, Hamilton Depression Scale （HAMD） and Clinical Global Impression （CGI） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results After treatment the HAMA and HAMD scores of both groups significantly continuously lowered compared with pretreatment （P〈0.05 or 0.01）, at the end of the pt week all scales scores were significantly lower in research than control group （P〈0.05）, there were no significant group differences in other time points （P〈 0.05） ; at the end of the 6th week total effective rate was respectively 78.8% in research and 81.3% in control group, which showed no significant group difference （P〉0.05）. The incidence of adverse reactions was respectively 12. 1% in research and 34.4% in control group, the former significantly lower than the latter （P〈0.05）. Conclusion ULF-rTMS takes effect more rapidly and has an evident effect and higher safety equivalent to paroxetine in the treatment of senile depression.

关 键 词：老年抑郁症 超低频重复经颅磁刺激 帕罗西汀 汉密顿焦虑量表 汉密顿抑郁量表 临床疗效总评量表 副反应量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]