重复经颅磁刺激辅助治疗老年抑郁症对照研究  

A control study of auxiliary repetitive transcranial magnetic stimulation for senile depression

作　　者：周春英[1] 吴淑云[1] 

机构地区：[1]南通市第四人民医院,江苏·南通226005

出　　处：《临床心身疾病杂志》2016年第5期19-21,共3页Journal of Clinical Psychosomatic Diseases

基　　金：南通市科技计划项目（编号HS13959）

摘　　要：目的探讨重复经颅磁刺激辅助治疗老年抑郁症患者的临床疗效和安全性。方法将61例老年抑郁症患者按随机数字表法分为研究组31例，对照组30例，均口服米氮平治疗，研究组联合重复经颅磁刺激治疗，观察4周。治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表评分均较治疗前持续下降（P〈0．05或0．01），研究组治疗第2周、4周末评分显著低于对照组（P〈0．05），同期总有效率显著高于对照组（P〈0．05）；两组不良反应较轻微，发生率比较差异无显著性（P〉0．05）。结论米氮平联合重复经颅磁刺激辅助治疗老年抑郁症患者具有协同增效作用，起效快，临床效果显著，安全性高，是治疗老年抑郁症患者的有效方法。Objective To explore the clinical efficacy and safety of auxiliary repetitive transcranial magnetic stimulation （rTMS） for senile depression. Methods Sixty one senile depression patients were randomly divided into research（n=31）and control group（n=30）, both groups took orally mirtazapine, research group was plus rTMS for 4 weeks. Efficacies were assessed with Hamilton Depression Scale （HAMD） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results After treatment the HAMD scores of both groups continuously lowered compared with pretreatment （P〈0.05 or 0.01）, those at the ends of the 2nd and 4th week were significantly lower （P〈 0.05） and total effective rates in the corresponding time period higher （P〈0.05） in research than control group; adverse reactions of both groups were mild and their incidences had no significant group differences （P〉0.05）. Conclusion Mirtazapine combined with rTMS has a synergism, takes effect more rapidly, has an evident effect and higher safety, and is an effective treatment method for senile depression.

关 键 词：老年抑郁症 重复经颅磁刺激 米氮平 辅助治疗 汉密顿抑郁量表 副反应量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]