枯否氏细胞在肝损伤中的作用研究进展  

Roles of Kupffer cells in liver injuries

作　　者：尤娜[1] 朱进[1] 汪茂荣[1] 

机构地区：[1]安徽医科大学附属第八一医院临床学院感染病科,合肥市230032

出　　处：《实用肝脏病杂志》2016年第5期633-636,共4页Journal of Practical Hepatology

摘　　要：枯否氏细胞在肝脏组织中起重要的保护屏障作用。在内毒素血症相关肝损伤中,枯否氏细胞与模式相关分子受体如Toll样受体结合,主要产生促炎细胞因子及其它化学分子,进而加速肝损伤的进程,而在药物性(如对乙酰氨基酚)肝损伤中,枯否氏细胞能分泌抗炎因子,促进肝脏血管生成,从而起保护作用。本文就近年来内毒素血症相关肝损伤和药物性肝损伤研究进展,对枯否氏细胞在肝脏损伤中的重要作用加以介绍。Kupffer cells serve as a protective barrier in the liver tissues. In endotoxinemia-induced liver injury,Kupffer cells produce pro-inflammatory cytokines and other chemical factors as they coupled with pattern recognition receptors such as Toll-like receptor,which can accelerate the processing of liver injury. Conversely,in drug-induced liver injury,such as acetaminophen-induced liver injury,Kupffer cells play several protective roles via secreting anti-inflammatory cytokines and promoting the formation of blood vessels in liver tissues. In this paper,we reviewed the vital role of Kupf er cells in the two types of liver injuries.

关 键 词：肝损伤 枯否氏细胞 内毒素血症 对乙酰氨基酚 

分 类 号：R575[医药卫生—消化系统]