普鲁卡因胺的合成研究  

Synthesis of Anti-arrhythmic

作　　者：周石洋[1,2] 杨善彬[1,2] 郭香琴 

机构地区：[1]重庆师范大学化学学院,重庆401331 [2]重庆师范大学活性物质生物技术教育部工程研究中心制剂工程研究所,重庆401331

出　　处：《精细化工中间体》2016年第4期36-38,64,共4页Fine Chemical Intermediates

摘　　要：以4-氨基苯甲酸为起始原料,经过酰氯化、酰胺化、N-烷基化3步反应合成抗心律失常药物普鲁卡因胺。对反应条件进行了优化,在优化反应条件下合成的总收率达83%。其中间产物和目标产物的化学结构均经~1H NMR、^(13)C NMR、MS等方法进行了表征。该合成方法操作简单,并提供了一条新的合成途径。A simple and high-yield synthetic method for the preparation of procainamide, an anti-arrhythmic drug, has been accomplished using 4-aminobenzoic acid as the starting material though a process including acylation, acetoxylation and N-alkylation reaction. The reaction conditions were optimized, and a typical yield of 83% was reached. The chemical structure of the target compound was characterized by ^1H NMR, ^13C NMR and MS.

关 键 词：普鲁卡因胺 优化 化学结构 

分 类 号：R914.5[医药卫生—药物化学]