局部晚期宫颈癌动静脉新辅助化疗卫生经济学比较研究  

Health economics comparsion of apporaches of neoadjuvant chemotherapy for locally advanced cervical cancer

作　　者：陈兰[1] 邓凯贤[1,2,3] 苏桂栋[1,2] 陈春林[1,2] 刘萍[1,2] 龚时鹏[1,2] 何晓峰[2] 李维丽[1,2] 王莉伶[1,2] 莫可欣[1,2,4] 刘云鹭 段慧[1,2] 

机构地区：[1]南方医科大学南方医院妇产科,广东广州510515 [2]南方医科大学南方医院介入科,广东广州510515 [3]佛山市妇幼保健院,广东佛山528000 [4]广州医科大学第五附属医院,广东广州510700

出　　处：《中国实用妇科与产科杂志》2016年第9期896-899,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：十二五国家支撑计划(2014BAI05B00);广东省自然科学基金重点项目(2015A030311024);广州市科技计划健康医疗协同创新重大专项(201508020264)

摘　　要：目的比较局部晚期宫颈癌(LACC)动脉新辅助化疗和全身静脉新辅助化疗的卫生经济学状况。方法选择2008年1月至2012年12月南方医科大学南方医院妇科住院行手术前新辅助化疗的LACC患者68例,按其化疗途径分为动脉化疗组(36例)和静脉化疗组(32例)。比较两组化疗近期疗效、疗程、不良反应及卫生经济学指标。结果两组化疗近期有效率相比较差异无统计学意义(91.66%vs.93.75%,P>0.05);静脉化疗组胃肠道反应和骨髓抑制作用均重于动脉化疗组(43.75%vs.33.33%,40.6%vs.13.89%,P<0.05);静脉化疗组化疗期间总住院费用、药物费用、总住院时间、总化疗时间、首次化疗距手术时间均显著高于动脉化疗组(P<0.01)。结论动脉新辅助化疗与静脉新辅助化疗近期疗效相当,但动脉新辅助化疗疗程短、不良反应少、住院费用及住院时间明显降低,符合卫生经济学的要求,是一种有效、经济的新辅助化疗方法。Objective To compare the health economics of arterial infusion neoadjuvant chemotherapy and intravenous neoadjuvant chemotherapy.Methods Clinical data of 68 patients who received neoadjuvant chemotherapy before operation with local late cervical cancer cervical cancer in Nanfang hospital from January 2008 to December 2012 were analysed retrospectively, which were divided into two groups according to different chemotherapy methods.The indexes of health economics and the chemotherapy effects, courses, adverse reactionsof two groups were compared. Results the chemotherapy effectsof these two groups had no statistically significant difference （P〉O.O5）.Gastrointestinal reaction and myelosuppression of intravenous systemic chemotherapy group were more serious than arterial infusion chemotherapy group （P〈0.05）.Total hospitalization expenses, drug cost, hospitalization time, total chemotherapeutic time, the time from primary chemotherapy to operation of intravenous systemic chemotherapy group were significantly higher than arterial infusion chemotherapy group （P〈0.01）.Conclusion The arterial approach of neoadjuvant chemotherapy is an economical and effective way, it has shorter courses, fewer adverse reactions, less hospitalization expenses while it has the equivalent levels of efficacy with the intravenous approach.

关 键 词：局部晚期宫颈癌 新辅助化疗 卫生经济学 

分 类 号：R737.3[医药卫生—肿瘤]