重症肌无力的分型及治疗新进展  

Advances in Classification and Therapy of Myasthenia Gravis

作　　者：郝茂林[1] 张桂茹[1] 冯建利[1] 杜怡峰[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250022

出　　处：《医学综述》2016年第18期3591-3595,共5页Medical Recapitulate

摘　　要：重症肌无力(MG)是一种神经肌肉接头传递障碍的自身免疫性疾病,发病机制尚不完全清楚。随着现代免疫抑制剂的发展以及症状治疗和支持治疗的改进,MG患者的预后良好。传统的Osserman分型主要是从临床症状的分布和疾病的轻重来分类,对治疗的选择意义不大。目前倾向于依据免疫学发病机制及临床特征将MG分为多个亚型,不同亚型的临床表现和对药物及胸腺手术的反应性也不同,临床应依据不同亚型制订相应的治疗方案。Myasthenia gravis （MG） is an autoimmune disease characterized by muscle weakness and fatigue. With modern immunosuppressive, symptomatic, and supportive treatments, the prognosis for MG patients is good. The traditional Osserman classification is mainly from the distribution of clinical symptoms and seriousness of the disease, which is not much helpful to the choice of treatment. There is a tendency to divide MG into several subtypes on the basis of immunological pathogenesis and clinical features, which have different clinical manifestations and responses to drugs and thymectomy,to guide to formulate corresponding treatments for different subtypes in clinical.

关 键 词：重症肌无力 亚组 自身抗体 

分 类 号：R743[医药卫生—神经病学与精神病学]