觉醒型卒中的研究进展  

The Progress of Wake-Up Stroke

作　　者：张然[1] 郭力[2] 

机构地区：[1]承德市中心医院神经内科,河北承德067000 [2]河北医科大学第二医院神经内科,石家庄050000

出　　处：《医学综述》2016年第18期3603-3606,共4页Medical Recapitulate

摘　　要：觉醒型卒中(WUS)是一类睡眠中起病,且发病时间不明的脑血管病。受到时间窗的限制,针对脑梗死最有效的重组组织型纤溶酶原激活剂溶栓治疗常难以实施。WUS独有的危险因素、病因、发病机制、临床表现及治疗的局限性决定了其不良预后。近年WUS逐渐成为临床研究热点,特别是基于影像学对缺血半暗带区的识别,以影像学指导的溶栓治疗及协同血管内治疗方案可能使该类患者临床获益。Wake-up stroke（WUS） ,with an unknown time of onset during sleep, usually represents a contraindication to thrombolysis with recombinant tissue plasminogen activator in stroke due to the limitation of the time window. With the unique risk factors, etiology, mechanisms, and clinical manifestations, there are many limitations in treatment, leading to poorer prognosis. In recent years, WUS has become a clinical re- search highlight, especially imaging based recognition of isehemie penumbra, imaging guided thrombolytie therapy and coordinated endovascular treatment may benefit the patients.

关 键 词：觉醒型卒中 危险因素 心房颤动 缺血半暗带 溶栓 

分 类 号：R743[医药卫生—神经病学与精神病学]