放射性海马功能障碍的研究现状  

Research status of hippocampal dysfunctions caused by cranial irradiation

作　　者：丁昕[1] 田野[1] 

机构地区：[1]苏州大学附属第二医院肿瘤放射治疗科苏州大学肿瘤放射治疗学研究所苏州市肿瘤放射治疗学重点实验室,215004

出　　处：《中华放射医学与防护杂志》2016年第9期712-716,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金（81372411,81402517）

摘　　要：颅脑放疗在脑部肿瘤的治疗中常规应用，但可能会造成不同程度的放射性脑损伤，尤其是对具有认知和情绪调控功能的海马组织。目前的研究表明，放射性海马功能障碍的发病机制可能与神经发生、神经营养因子以及神经炎症相关，并提出运动锻炼、丰富环境、抗炎治疗和神经干细胞移植等可能有效的防治策略。本文将放射性海马功能障碍的研究进展及面临的挑战进行综述，旨在为未来的基础和临床研究提供有利的切入点。Cranial irradiation is routinely used for the treatment of ahnost all brain tumors, but it may cause disastrous injury in brain, especially in the hippocampus that has cognitional and emotional regulation functions. Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis, neurotrophin and neuroinflammation, and provided effective prevention strategies such as exercise, environmental enrichment, anti-inflammatory and intrahippocampal transplantation of neural stem cells. This review discussed the current progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches.

关 键 词：放射治疗:海马功能障碍 神经发生 

分 类 号：R739.41[医药卫生—肿瘤] R730.55[医药卫生—临床医学]