非线性建模红外光谱法测定对乙酰氨基酚原料药的含量  

Content Determination of Paracetamol by the Nonlinear Quantitative Model with Infrared Spectroscopy

作　　者：裘兰兰[1] 李明梅[1] 

机构地区：[1]盐城卫生职业技术学院,江苏盐城224005

出　　处：《中国药房》2016年第27期3850-3852,共3页China Pharmacy

基　　金：江苏省高校品牌专业建设工程资助项目(No.PPZY2015A097);江苏省教育厅高校优秀中青年教师和校长境外研修项目

摘　　要：目的:为利用红外光谱法进行对乙酰氨基酚无损检测提供理论依据。方法:准确称取0.002~0.02 g的对乙酰氨基酚原料药,分别加入0.2 g的溴化钾,充分研磨并混合均匀,采用溴化钾压片法配制成待测供试品。光源使用空心阴极灯,扫描频次为30次,分辨率0.5 cm^(-1),扫描范围4 000~400 cm^(-1),测定并记录红外吸收光谱,对药物的特征吸收峰进行筛选,从而确定最佳的特征吸收峰。运用数学建模方法分别建立线性模型和非线性模型。结果:本试验选择用吸光强度较弱但特征性较强的1 016 cm^(-1)吸收峰进行分析。通过建立模型并进行计算可知,非线性模型检测的准确性远高于线性模型检测的准确性,非线性模型方程的r=0.942。结论:非线性建模红外光谱法测定对乙酰氨基酚原料药含量是可行的,其适用于对乙酰氨基酚的无损、快速在线质量控制。OBJECTIVE： To provide theoretical basis for the detection of paracetamol by infrared spectroscopy. METHODS： 0.002-0.02 g paracetamol was accurately weighed, added into 0.2 g potassium bromide, respectively, fully ground and well mixed, potassium bromide pressing plate method was used for to-be-tested test sample. Using hollow cathode lamp as light, scanning fre- quency was 30 times, resolution was 0.5 cm-1, scan range was 4000-400 cm-1, infrared absorption spectrum was determined and recorded to select the characteristic absorption peaks, then determine the optimized characteristic absorption peaks. Linear and non- linear models were respectively established by using mathematics modeling methods. RESULTS： 1 016 cm-1 absorption peak with weaker absorbance but stronger features was selected for the analysis. According to the model establishing and calculation, the accu- racy of the nonlinear model was much higher than the linear model, r=0.942. CONCLUSIONS： Nonlinear quantitative model for quantitatively determining the content of paracetamol is feasible, and suitable for the on-destructive and rapid on-line quality control of paracetamol.

关 键 词：对乙酰氨基酚 非线性模型 红外光谱法 含量测定 

分 类 号：R927.2[医药卫生—药学]