3种治疗视网膜分支静脉阻塞并发黄斑水肿方法的疗效观察  

Curative effect of three kinds of treatment methods on branch retinal vein occlusion combined with macular edema

作　　者：邢战中[1] 吕杰[1] 李冬梅[1] 王翠[1] 马军艳[1] 

机构地区：[1]焦作煤业(集团)有限责任公司中央医院眼科,焦作454000

出　　处：《中国眼耳鼻喉科杂志》2016年第5期333-336,共4页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的评价3种治疗视网膜分支静脉阻塞(BRVO)并发黄斑水肿(ME)方法的疗效及其安全性。方法将60例(60眼)BRVO并发ME患者随机分为A、B、C组,A组20例接受视网膜光凝治疗,B组20例接受1次康柏西普玻璃体腔注射及视网膜光凝治疗,C组20例每月1次单纯玻璃体腔注射康柏西普注射液。从治疗开始到复诊结束共6个月。比较3组患者治疗6个月时最佳矫正视力(BCVA)和黄斑中心凹区视网膜厚度(CMT),观察3组所发生的不良反应。结果在治疗6个月时,A、B、C 3组的平均BCVA分别是:0.24±0.12,0.31±0.12,0.42±0.11;平均CMT分别是:(366.13±157.55),(280.02±100.02),(199.35±50.86)μm,3组与各自治疗前及3组间差异有统计学意义(P<0.05)。观察期内3组患者均未发生严重并发症。结论 3种治疗BRVO合并ME的方法均是安全、有效的,其中康柏西普注射液连续3次玻璃体腔注射较其他2种方法疗效好。Objective To evaluate the efficacy and safety of three methods on branch retinal vein occlusion （BRVO） combined with macular edema （ME）. Methods Sixty patients （60 eyes） with BRVO and ME were randomly divided into group A, B and C. Group A of 20 cases were treated with retinal photocoagulation; group B of 20 cases received once conbercept ophthalmic injection intravitreal injection and retinal photocoagulation; group C of 20 cases underwent vitreous cavity injection conbercept ophthalmic injection once a month. The best corrected visual acuity （BCVA） and central macular thickness （CMT） were compared among the 3 groups after 6 months of treatment and adverse reactions were observed in the 3 groups from the start of treatment to the end of the observation period of 6 months. Results The average BCVA values of A, B and C were 0.24 ± 0.12, 0.31± 0.12, 0.42 ± 0.11, respectively and the average CMT were： （366.13 ± 157.55）, （280.02 ± 100.02）, （ 199.35 ±50.86） μm at 6th month of treatment. There were statistically significant differences among the 3 groups before treatment （P 〈 0.05 ）. No serious complication was observed in the 3 groups during the observation period. Conclusions The three methods are safe and effective for the treatment of BRVO combined with ME. Three consecutive conbercept intravitreal injection in the treatment of BRVO combined with ME has better curative effect than the other 2 methods.

关 键 词：视网膜分支静脉阻塞 黄斑水肿 康柏西普注射液 视网膜光凝 玻璃体腔注药 

分 类 号：R779.63[医药卫生—眼科]