泪道栓子治疗重度干眼症的临床研究  

Clinical research on lacrimal plug in the treatment of severe dry eyes

作　　者：邹浩东 李娟[1] 刘小虎[1] 童继威 

机构地区：[1]四川省乐山市中医医院眼科,乐山614000

出　　处：《中国眼耳鼻喉科杂志》2016年第5期352-354,共3页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的对比研究新型泪道栓子Smart PlugTM和人工泪液治疗重度干眼症的临床效果。方法观察94例(120眼)重度干眼症患者,随机分为对照组和试验组。对照组采用人工泪液滴眼,试验组予以下泪小点植入Smart Plug^(TM)泪道栓子,对比评价2组治疗前及治疗后1个月、3个月的主观症状评分、泪液分泌试验、泪膜破裂时间(BUT)及角膜荧光染色(FL)评分情况。结果试验组和对照组在治疗前主观症状评分分别为7.62±1.03和7.65±1.09,泪液分泌试验分别为(2.63±0.71)mm和(2.53±0.77)mm,BUT分别为(2.67±0.80)和(2.62±0.76)s,角膜FL评分分别为9.08±1.55和8.75±1.56,2组差异均无统计学意义(P值均>0.05)。而在治疗1个月后以及治疗3个月后,2组间各项指标差异均有统计学意义(P<0.05),且试验组的主观症状评分、泪液分泌试验、BUT及角膜FL评分改善较对照组更为明显。结论使用Smart PlugTM泪道栓子可以明显改善重度干眼症的临床症状,且治疗效果优于常规人工泪液的治疗。Objective To investigate and compare the efficacy of lacrimal plug insertion and artificial lacrima on severe dry eyes. Methods Ninety-four cases （ 120 eyes ） with severe dry eyes were divided into two groups randomly. One group received SmartPlugTM-lacrimal plugs which was located in inferior puncture and the other group received artificial lacrima for routine treatment. Personal symptoms scores, Schirmer test, tear film break-up time and corneal fluorescein staining scores before and after treatment for 1 month and 3 months were recorded and compared in two groups. Results There were no significant differences in personal symptoms scores, Schirmer test, tear film break-up time and corneal fluorescein staining scores between two groups before the treatment （ all P 〉 0.05 ）. While after treatment for 1 month and 3 months, patients received lacrimal plugs had improvement in personal symptoms scores, Schirmer test, tear fibn break-up time and corneal ilnorescein staining scores compared to the artificial lacrima group with significant differences （ all P 〈 0. 05 ）. Conclusions SmartPlugTM lacrimal plug can obviously improve the severe dry eyes＇ symptom, and a better therapeutic effect of SmartPlugTM lacrimal plug can be achieved compared to artificial lacrima.

关 键 词：干眼症 泪道栓子 泪液分泌试验 泪膜破裂时间 角膜荧光染色 

分 类 号：R777.34[医药卫生—眼科]