腺苷酸活化的蛋白激酶在乳腺癌辅助治疗中作用的研究进展  

Research progression of AMPK in adjuvant treatment strategy of breast cancer

作　　者：陈涛[1] 曾慧娟[1] 王少华[1] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)解放军普通外科研究所,南京医学硕士研究生210002

出　　处：《医学研究生学报》2016年第9期993-998,共6页Journal of Medical Postgraduates

基　　金：国家重点发展计划973项目(2014CB744500)

摘　　要：腺苷酸活化的蛋白激酶(AMP activated protein kinase,AMPK)是细胞内重要的能量感受器,在调控细胞和机体的能量代谢中起着极其重要的作用。AMPK与不同类型乳腺癌细胞的存活存在密切而复杂的联系,根据条件的不同,AMPK可能同时存在抗肿瘤或促进肿瘤的作用。文中从AMPK与乳腺癌相关信号通路的关系,AMP与乳腺癌内分泌治疗、乳腺癌化疗、乳腺癌放疗、三阴性乳腺癌治疗及多药物耐药的关系进行综述,并阐述了AMPK相关药物应用。Activated protein kinase （AMPK）, an important energy receptor, plays a very important role in regulating organ- ism and the energy metabohsm of the cell. AMPK has complex relationship with survival of different types of breast cancer cells. Ac- cording to different conditions, AMPK may exist both anti or promoting effect on tumor. In this review, we summarize the relationship between AMPK and breast cancer related signal pathways, AMP and breast cancer endocrine therapy, breast cancer chemotherapy, ra- diotherapy for breast cancer, treatment of triple negative breast cancer and multi drug resistance of the relationship, we also expound some drugs related to AMPK and used in clinical setting.

关 键 词：乳腺癌 AMPK信号通路 能量代谢 

分 类 号：R737.9[医药卫生—肿瘤]