氨基水杨酸类联合微生态制剂维持治疗溃疡性结肠炎的效果  

Effect of amino salicylic acid combined with probiotics for the maintenance treatment of ulcerative colitis

作　　者：车军 贾泽博 王永席 翟红兵 王莎莎 马锦屏 苏丽萍 王欣 

机构地区：[1]咸阳市中心医院消化内科,陕西咸阳712000

出　　处：《胃肠病学和肝病学杂志》2016年第9期1047-1049,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨氨基水杨酸类联合微生态制剂维持治疗溃疡性结肠炎(ulcerative colitis,UC)的效果,为UC的临床治疗提供一定参考。方法收集2014年01月–2015年01月咸阳市中心医院收治的74例UC患者,随机分为对照组和观察组,每组37例。对照组患者服用美沙拉嗪进行治疗,观察组患者在服用美沙拉嗪的同时服用双歧杆菌四联活菌片进行治疗,两组患者均维持治疗1年。治疗前后检测患者的超敏C-反应蛋白(Hs-CRP)及肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)水平的变化,并比较两组患者的临床疗效,记录不良反应的发生情况。结果治疗后观察组的总有效率(97.30%)明显优于对照组(83.78%),差异有统计学意义(P<0.05);治疗后两组患者Hs-CRP、IL-8及TNF-α均较治疗前显著改善,差异均具有统计学意义(P<0.05),且观察组Hs-CRP、IL-8及TNF-α较对照组明显降低,差异均具有统计学意义(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论氨基水杨酸类联合微生态制剂对UC的维持治疗效果较好,值得在临床工作中推广。Objective To investigate the effect of amino salicylic acid combined with probiotics for the maintenance treatment of ulcerative colitis （UC） , and provide a reference for the clinical treatment. Methods From Jan. 2014 to Jan. 2015 in Xianyang Central Hospital, 74 patients with UC were randomly divided into control group and observation group, 37 cases in each group. Patients in control group were taken mesalazine treatment and patients in observation group were taken mesalazine treatment combined with Bifidobacterium teravaccine tables, all the patients were main- tained one year of treatment. Hypersensitive C-reactive protein （Hs-CRP） and tumor necrosis factor-α （TNF-α）, inter- leukin-8 （IL-8） were detected before and ofter treatment. Clinical efficacy was compared between two groups, the α- currence of adverse reactions was recorded. Results After the treatment, total effective rate （97.30%） in observation group was higher than that in control group （83.78%）, the difference was statistically significant （P 〈 0.05 ） ; after the treatment, Hs-CRP, IL-8 and TNF-αsignificantly improved than before in the two groups, the difference was statistically significant （P 〈 0.05 ）. The Hs-CRP, IL-8 and TNF-α were significant decreased in observation group compared with control group after treatment, the difference was statistically significance （P 〈 0.05） ; the incidence of adverse reactions was no statistical significance between two groups （P 〉 0.05）. Conclusion The amino salicylic acid combined with probiotics for the maintenance therapy of UC is better, and it is worthy of promotion in clinical work.

关 键 词：氨基水杨酸类 美沙拉嗪 微生态制剂 双歧杆菌四联活菌片 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]