盐酸埃克替尼致便血  

Hemafecia due to icotinib hydrochloride

作　　者：林秀丽[1] 曾惠清[1] 蔡雪莹[1] 

机构地区：[1]厦门大学附属中山医院/福建医科大学厦门中山教学医院呼吸内科,361004

出　　处：《药物不良反应杂志》2016年第4期300-301,共2页Adverse Drug Reactions Journal

摘　　要：1例68岁女性患者因肺癌并全身多发骨转移口服盐酸埃克替尼0．125mg，3次／d。第2天患者出现少量鲜血便，约20ml，遂自行停药。第3天便血停止。第4天，遵医嘱再次按原剂量口服盐酸埃克替尼。第5天，患者排鲜血便3次，出血量约100～150ml，实验室检查示PLT43×10^9／L（服药前37×10^9／L），Hb119g／L（服药前132g／L）。再次停用盐酸埃克替尼，观察4d，患者未再便血。A 68-year-old female patient received icotinib hydrochloride 0. 125 mg thrice daily due to lung cancer with systemic multiple bone metastases. On the second day, the patient developed hematochezia with an amount of 20 ml blood in stool. Icotinib hydrochloride was stopped by herself. On the third day, hemafecia disappeared. On the fourth day, she restarted icotinib hydrochloride at the same dosage following the doctor＇s advice. On the 5th day, hemafecia three times appeared, which was about 100-150 ml. Laboratory tests showed that platelet was 43 × 10^9/L （37 × 10^9/L before the drug administration） and hemoglobin was 119 g/L（ 132 g/L before the drug administration）. Icotinib hydrochloride was withdrawn and the hemafecia did not recur for 4 days.

关 键 词：埃克替尼 便血 

分 类 号：R734.2[医药卫生—肿瘤]