阿昔洛韦致视物模糊  

Blurred vision induced by acyclovir

作　　者：沈渠深[1] 陈炽邦 周永恒[1] 彭南星 刘春霞[1] 

机构地区：[1]广州市增城区人民医院/中山大学附属博济医院药剂科,511300 [2]广州市增城区人民医院/中山大学附属博济医院神经内科,511300

出　　处：《药物不良反应杂志》2016年第4期314-316,共3页Adverse Drug Reactions Journal

摘　　要：1例24岁男性患者因病毒性脑膜脑炎给予阿昔洛韦（0.5 g静脉滴注、3次/d）、醒脑静注射液（20 ml静脉滴注、1次/d）、甘露醇注射液（250 ml快速静脉滴注、3次/d）、磷酸肌酸钠（1 g静脉滴注、1次/d）、胰岛素注射液（6 U＋5%葡萄糖注射液500 ml＋氯化钾注射液10 ml静脉滴注、1次/d）、血栓通注射液（500 mg静脉滴注、1次/d）、甲钴胺注射液（2 ml静脉滴注、1次/d）、枸橼酸铋雷尼替丁胶囊（0.2 g口服、2次/d）和丁苯酞软胶囊（0.2 g口服、3次/d）等治疗。第7天，患者出现视朦，视远物不清，瞳孔扩大，直径约5.0 mm，结膜充血。停用阿昔洛韦，其他药物继续使用。5 d后，患者结膜充血有所改善，瞳孔稍有缩小，视力有所好转。随访2个月，患者未再出现视物模糊。A 24-year-old male patient with viral meningoencephalitis received intravenous infusion of acyclovir 0.5 g thrice daily, Xingnaojing injection （醒脑静注射液） 20 ml once daily, mannitol injection 250 ml thrice daily, creatine phosphate sodium 1 g once daily, insulin injection （6 U＋5% glucose injection 500 ml＋ potassium chloride injection 10 ml）, Xueshuantong injection （血栓通注射液） 500 mg once daily, mecobalamin injection 2 ml once daily, and oral butylphthalide soft capsules 0.2 g thrice daily, ranitidine bismuth citrate capsules 0.2 g twice daily, etc. On day 7, the patient developed visual blurring and could not see distant objects clearly. At the same time, the patient experienced mydriasis with diameter about 5.0 mm and conjunctival congestion. Acyclovir was discontinued and other drugs were continued. Five days after withdrawal, his symptoms of conjunctival congestion, mydriasis, and vision were improved. At 2 months of follow-up, blurred vision did not recur.

关 键 词：阿昔洛韦 视觉障碍 

分 类 号：R978.7[医药卫生—药品]