D-二聚体、NT-proBNP及脂蛋白(a)在急性缺血性脑卒中患者的水平及临床意义  

The clinical significance of D-two,NT-proBNP and serum lipoprotein(a)level in patients with acute ischemic stroke

作　　者：蔡德建[1,2] 田玫玲[2] 卢庆乐[2] 

机构地区：[1]山东大学医学院免疫研究所,济南250021 [2]山东大学附属省立医院检验科,济南250022

出　　处：《国际检验医学杂志》2016年第18期2550-2552,共3页International Journal of Laboratory Medicine

摘　　要：目的研究D-二聚体、N末端-脑钠肽前体(NT-proBNP)及脂蛋白(a)在急性缺血性脑卒中患者的水平及临床意义。方法选择2013年3月至2015年3月接诊的150例急性缺血性脑卒中患者作为观察组进行研究。并选择同期进行健康体检者50例作为对照组。分别对2组对象的D-二聚体、NT-proBNP及脂蛋白(a)水平进行检测。依据神经功能缺损评分对脑卒中患者进行分组,对3项指标进行统计分析。结果观察组患者的D-二聚体、NT-proBNP及血清脂蛋白(a)水平明显高于对照组,2组比较差异有统计学意义(P<0.05)。重型患者的D-二聚体、NT-proBNP及血清脂蛋白(a)水平明显高于轻型和中型,随着病情程度加重,3项指标的水平逐渐升高(P<0.05)。腔隙性脑卒中患者的D-二聚体、NT-proBNP及血清脂蛋白(a)水平明显高于非腔隙性组患者(P<0.05)。结论 D-二聚体、NT-proBNP及血清脂蛋白(a)在急性缺血性脑卒中患者诊断中临床诊断价值较高,值得广泛应用。Objective To study the clinical significance of D-D,NT-proBNP and serum lipoprotein（a）level in patients with acute ischemic stroke.Methods 150 cases of patients with acute ischemic stroke from March 2013 to March 2015 were selected as the observation group.And 50 cases of healthy physical examination were selected as control group.The levels of D-D,NT-proBNP and serum lipoprotein（a）were detected in D groups.According to the nerve function defect score,the three indexes were analyzed and studied.Results The D-D polymer,NT-proBNP and serum lipoprotein（a）levels in the observation group were significantly higher than those in the control group,the D groups were statistically significant（P〈0.05）.The levels of D-D,NT-proBNP and serum lipoprotein（a）in the patients with severe were significantly higher than those in light and medium,and the level of the three indexes increased gradually（P〈0.05）with the severity of the disease.Lacunar stroke with the D-dimer,NT-proBNP and serum lipid protein（a）level was significantly higher than that in non lacunar group patients（P〈0.05）.Conclusion D-D,NT-proBNP and serum lipoprotein（a）in the diagnosis of acute ischemic stroke patients are high clinical value,it is worth popularizing widely.

关 键 词：急性缺血性脑卒中 D-二聚体 N末端-脑钠肽前体 血清脂蛋白(a) 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.1[医药卫生—临床医学]