副肿瘤性周围神经病18例临床特点分析  

Clinical features analysis of 18 cases of paraneoplastic peripheral neuropathy

作　　者：黄宝和[1] 是明启[1] 邵春香[1] 

机构地区：[1]河南省焦作市焦煤集团中央医院神经内科,454000

出　　处：《中国实用医刊》2016年第17期17-19,共3页Chinese Journal of Practical Medicine

摘　　要：目的：探讨副肿瘤性周围神经病（PPN）的临床特点。方法回顾性总结分析2005年3月至2015年8月收治的18例 PPN 患者的临床资料。结果本研究患者发病年龄为（48.9±18.0）岁，男13例，女5例。5.6%的患者在发现肿瘤后才出现周围神经病症状，94.4%在出现周围神经症状后才发现肿瘤。诊断出 PPN 时，33.3%肿瘤已出现转移。从出现周围神经病症状至发现肿瘤时间为（16±7）个月，患者多为慢性隐袭或亚急性起病，症状进行性加重。结论 PPN 的临床症状可发生在肿瘤发现之前、之后或与之同时发生，PPN 的出现预示预后差。临床早期诊断对于及时发现和治疗癌肿至关重要。Objective To investigate the clinical characteristics of paraneoplastic peripheral neuropathy（PPN）. Methods The clinical data of 18 patients with PPN from March 2005 to Augest 2013 were retrospectively analyzed. Results The age of onset in the group was（48. 9 ± 18. 0）years old,13 male and 5 female. 5. 6% of the patients had symptoms of peripheral neuropathy after found the tumor,94. 4% found the tumor after the peripheral nervous symptoms appeared. When the PPN was found,33. 3% of the tumor metastasis had been transferred. From the onset of peripheral neuropathy symptoms to find the tumor,the time was（16 ± 7）months. The onset of the disease was chronic insidi-ous or subacute and the symptoms were progressive. Conclusions The clinical symptoms of PPN may occur in the tumor before,after or at the same time,the occurrence of PPN indicates a poor prognosis. The early clinical diagnosis for timely detection and treatment of cancer is very important.

关 键 词：副肿瘤性周围神经病 临床表现 早期诊断 

分 类 号：R739.4[医药卫生—肿瘤] R745[医药卫生—临床医学]