酒依赖患者戒断所致震颤谵妄认知功能研究  

Cognitive function after delirium tremens in patients with alcohol dependence

作　　者：李强笃[1] 孙立娟[1] 马红[1] 陈珍利 张丹宁[2] 

机构地区：[1]新汶矿业集团莱芜中心医院,山东莱芜271103 [2]山东省精神卫生中心

出　　处：《精神医学杂志》2016年第4期256-258,共3页Journal of Psychiatry

摘　　要：目的探究酒精戒断中震颤谵妄的发生对患者认知功能的影响。方法选取近2年136例首次住院的男性酒依赖患者在脱瘾过程中按照是否出现震颤谵妄(DT)分为两组,采用韦氏成人智力量表(WAIS)、韦氏记忆量表(WMS)、事件相关电位P300分别评定其认知功能。结果震颤谵妄组WAIS量表IQ、言语智商、操作智商总分及领悟、算术、数字广度、数字符号、填图、木块图、图形排列、拼图因子分均低于非震颤谵妄组(P<0.01)。震颤谵妄组WMS量表各因子分均低于非震颤谵妄组(P<0.01)。与非震颤谵妄组相比,震颤谵妄组P300潜伏期延长,波幅降低(P<0.01)。结论酒精戒断过程中震颤谵妄的发生会加重认知功能的损害。Objective To investigate the cognitive function after delirium tremens in patients with alcohol dependence.Methods 136 male alcohol-dependent patients were divided into delirium tremens group（ DT group） and non-delirium tremens group（ non-DT group） in terms of delirium tremens occurrence. All patients were assessed with Wechsler Adult Intelligence Scale（ WAIS）,Wechsler Memory Scale（ WMS） and event-related potential P300 to evaluate their cognitive function. Results Total IQ,verbal IQ,performance IQ,as well as factor scores of comprehension,count,digit span,digit symbol,platting,block design,graph pattern and puzzle of WAIS were significantly lower in DT group than those in non-DT group（ P〈0. 01）. All factor scores of WMS were significantly lower in DT group than those in non-DT group（ P〈0. 01）. Compared with non-DT group,P300 latency was longer and amplitude was lower in DT group（ P〈0. 01）. Conclusion Delirium tremens may aggravate cognitive impairments in the course of alcohol withdrawal.

关 键 词：酒依赖 震颤谵妄 事件相关电位 P300 认知功能 

分 类 号：R749.62[医药卫生—神经病学与精神病学]