氨磺必利与利培酮治疗伴抑郁症状的精神分裂症对照研究  

A control study of amisulpride vs. risperidone in the treatment of schizophrenia with depressive symptoms

作　　者：于晓东[1] 季加翠[1] 林正华 张敬悬[1] 

机构地区：[1]山东省精神卫生中心,山东济南250014 [2]聊城市第四人民医院

出　　处：《精神医学杂志》2016年第4期277-279,共3页Journal of Psychiatry

摘　　要：目的探讨氨磺必利治疗合并抑郁症状的精神分裂症患者的临床疗效。方法将60例合并抑郁症状的精神分裂症患者随机分为观察组和对照组各30例,观察组采用氨磺必利治疗,对照组采用利培酮治疗,采用阳性和阴性综合征量表(PANSS)、汉密尔顿抑郁量表(HAMD)和治疗中需处理的不良反应症状量表(TESS)比较两组的疗效及不良反应。结果治疗后观察组PANSS阴性症状减分和HAMD减分均大于对照组(P<0.05);观察组总有效率高于对照组(P<0.05)。观察组总不良反应发生率低于对照组(P<0.05)。结论氨磺必利能显著缓解精神分裂症患者的阴性症状,同时降低抑郁程度,且不良反应少。Objective To explore the efficiency of amisulpride in the treatment of schizophrenia with depressive symptoms.Methods 60 schizophrenic patients with depressive symptoms were randomized into study group（ 30 cases） treated with amisulpride and control group（ 30 cases） treated with risperidone for 8 weeks. All patients were assessed with Positive and Negative Syndrome Scale（ PANSS）,Hamilton Depression Scale（ HAMD） and Treatment Emergent Symptom Scale（ TESS） at baseline and at the end of the treatment. Result Reductions of factor score of negative symptoms in PANSS and HAMD in study group were significantly higher than those in control group（ P〈0. 05）. Effective rate was significantly higher in study group than that in control group（ P〈0. 05）. Incidence rate of side effects was significantly lower in study group than that in control group（ P〈0. 05）. Conclusion Amisulpride can improve effectively negative symptoms and depressive symptoms of schizophrenia with less adverse reactions.

关 键 词：氨磺必利 抑郁 精神分裂症 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]