肿瘤标志物CA199和CEA与大便潜血联合检测对肠癌复发的诊断价值  

Diagnostic value of combined detection of tumor markers CA199 and CEA with fecal occult blood in the diagnosis of the recurrence of colorectal cancer

作　　者：罗锦彬 林健谊 

机构地区：[1]惠州市第六人民医院检验科,广东惠州516211

出　　处：《华夏医学》2016年第4期85-88,共4页Acta Medicinae Sinica

摘　　要：目的:探讨肿瘤标志物CA199和CEA与大便潜血联合检测对肠癌复发诊断价值。方法:选取2010年4月至2005年11月我院收治肠癌术后患者87例为研究对象,检测患者CA199和CEA水平及大便潜血,以肠镜病理检查为诊断"金标准",判定CA199、CEA、大便潜血及三者联合检测在肠癌术后复发中诊断灵敏度和特异性。结果:87例患者经肠镜检查并去病理组织检查,明确诊断为肠癌复发41例,复发率为47.13%。CA199在肠癌复发中检测灵敏度为48.78%,特异性为76.09%。CEA在肠癌复发中检测灵敏度为58.54%,特异性为78.26%。大便潜血在肠癌复发中检测灵敏度为36.59%,特异性为60.87%。CA199、CE及大便潜血联合检测在肠癌复发中检测灵敏度为70.73%,特异性为52.17%。结论:肿瘤标志物CA199、CEA、大便潜血在肠癌复发中单独检测诊断灵敏度较低,特异度较高,三者联合检测可提高灵敏度,但可降低特异度,临床中应采用三者联合检测,对于阳性患者应早期进行肠镜检查并取病理组织,以早诊断、早治疗,提高疗效,改善患者预后。Objcctivc： To investlgatc the valuc of tumor markers CA199 and CEA combined with fecal occult blood in the diagnosis of the recurrence of colorectal cancer. Methods： 87 cases of colorectal cancer patients admitted into our hospital for treatment from April 2010 to November 2005 were selected in the study. CA199 and CEA levels, and fecal occult blood were detected, and colonoscopy with biopsy were used as the ＂gold standard＂ for determining the diagnostic sensitivity and specificity of CA199, CEA, and fecal occult blood, and com- bined three as well in the diagnosis of the recurrence of colorectal cancer. Results： It was confirmed that 41 of 87 patients suffered from recurrence of colorectal cancer through colonoscopy and histopathological examination with a recurrence rate of 47.13%. The detection sensitivity and specificiW of CA199, CEA and fecal occult blood were 48.78% vs 76.09%; 58.54% vs 78.26%; 36.59% vs 60.87% respectively hi detecting the recurrence of colorectal cancer. The detection sensitivity and specificity of the combined 3 markers in the detection of colorectal cancer recurrence was 70.73% and 52.17% .Conclusion： The single use of tumor markers CA199, CEA and fecal occult blood has lower sensitivity but high specificity in the detection and diagnosis of colorectal cancer recurrence, and the combined 3 markers may improve the detection sensitivity but lower the specificity. It is suggested that the combined detections with 3 markers be adopted in clinical practice, and positive patients should conduct early colonoscopy and pathology. Early diagnosis and early treatment can improve the efficacy and improve the pa- tients＇ prognosis.

关 键 词：肿瘤标志物 肠癌 复发 大便潜血 

分 类 号：R735.3[医药卫生—肿瘤]