肿瘤抑制基因RECK的表观调控研究进展  

Progress in epigenetic regulation of the tumor suppressor gene RECK

作　　者：宁士龙 马宵[1] 李忠[1] 

机构地区：[1]南京医科大学公共卫生学院营养与食品卫生学系,211166

出　　处：《肿瘤研究与临床》2016年第8期565-568,共4页Cancer Research and Clinic

基　　金：国家自然科学基金（81171987）

摘　　要：RECK蛋白在正常细胞和组织中表达量很高,但在发生恶转的细胞和肿瘤组织中表达下调,后续的功能研究证明RECK具有肿瘤抑制功能,因此阐明支配细胞内RECK基因表达的调控机制显得尤为重要.表观调控在调节体内基因表达过程中发挥了重要的作用,而且众多研究也表明RECK基因受表观调控.文章综述到目前为止发现的能够表观调控RECK基因表达的机制.The RECK protein is highly expressed in normal cells and tissues,however,down-regulated in transformed cells or tumor tissues.Subsequent functional studies have demonstrated that RECK owns the tumor suppressor activity.Hence,it is urgent and important to unmask the mechanisms involved in regulation of RECK expression.Epigenetic regulation plays a vital role in modulating gene expression,besides,multiple research also suggested the involvement of epigenetic regulation in RECK expression.The epigenetic regulation mechanisms of controlling the gene expression currently known will be reviewed in this paper.

关 键 词：肿瘤 RECK基因 表观调控 DNA甲基化 非编码RNA 组蛋白去乙酰化酶 

分 类 号：R730.2[医药卫生—肿瘤]