非小细胞肺癌组织中Snail、E-cadherin及N-cadherin的表达及临床意义  

Expression of Snail,E-cadherin and N-cadherin in tissues of non-small cell lung cancer and its clinical significance

作　　者：俞婷婷[1] 刘莉[1] 王若峥[2] 

机构地区：[1]新疆医科大学附属肿瘤医院肺内科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院头颈放射治疗科,新疆乌鲁木齐830011

出　　处：《实用临床医药杂志》2016年第17期29-31,56,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11522488)

摘　　要：目的探讨指转录因子Snail、上皮细胞钙粘蛋白(E-cadherin)及神经钙黏素(N-cadherin)在非小细胞肺癌组织中的表达及其之间的相关性。方法采用免疫组化法检测63例非小细胞肺癌(NSCLC)手术切除标本及30例癌旁组织中Snail、E-cadherin、N-cadherin蛋白的表达,并分析相互间关系及其临床意义。结果与癌旁组织比较,NSCLC组织中E-cadherin表达显著减少,N-cadherin和Snail表达明显增加(P<0.01)。NSCLC组织中,Snail的表达与N-cadherin呈明显的正相关(P<0.05,r=0.33),与E-cadherin呈显著负相关(P<0.05,r=-0.41),N-cadherinl的表达与E-cadheri也呈明显负相关(P<0.05,r=-0.56)。Snail表达阳性率与TNM分期和有无转移相关(P<0.05);E-cadherin表达阳性率与TNM分期和有无转移相关(P<0.05);N-cadherin表达阳性率与组织学分型、TNM分期和有无转移相关(P<0.05)。结论 NSCLC癌组织中Snail、E-cadherin和N-cadherin表达水平与肿瘤的浸润转移密切相关,可作为临床诊断和治疗靶点的参考指标。Objective To explore the and nerve-cadherin （N-cadherin） in the tissues expression of Snail, epithelial-cadherin （E-cadherin） of non-small cell lung cancer （NSCLC） and their re- lationships. Methods Immunohistochemical method was used to detect the levels of Snail, E-cad- herin and N-cadherin protein expression in surgically resection tissue samples from 63 patients with NSCLC and para-cancerous tissues was obtained from 30 patients, and the relationships among them and their clinical significance were analyzed. Results Compared with para-cancerous tissues, NSCLC tissues had evidently decreased E-eadherin expression and notably increased expression of N- cadherin and Snail （ P 〈 0. 0 1）. In NSCLC tissues, the expression of Snail was in positive association with that of N-cadherin （ P 〈 0.05, r = 0.33 ） and in negative connection with that of E-cadherin （P 〈 0.05, r = - 0.41 ）, whereas expression of N-cadherinl was negatively related with that of E- cadheri （ P 〈 0.05, r = - 0.56）. The positive expression rates of Snail and E-cadherin were in close association with TNM staging and whether there was metastasis （ P 〈 0.05 ）, whereas that of N-cad- herin had close association with histological classification, TNM staging and whether there was metas- tasis （ P 〈 0.05 ）. Conclusion The expression levels of Snail, E-cadherin and N-cadherin in NSCLC cancerous tissues are associated with tumor infiltration and metastasis, so they can be used as reference indexes for the clinical diagnosis and therapeutic targets.

关 键 词：非小细胞肺癌 锌指转录因子 上皮细胞钙粘蛋白 神经钙黏素 免疫 

分 类 号：R734.2[医药卫生—肿瘤]