细菌性肝脓肿合并糖尿病与非合并糖尿病患者的病原菌学分析  

Comparative analysis of pathogens in diabetic and non-diabetic patients with hepatic abscess

作　　者：王静[1] 李美晔[1] 尹朝晖[1] 姜兆顺[1] 

机构地区：[1]济南军区总医院内分泌科,250031

出　　处：《中华消化病与影像杂志（电子版）》2016年第5期201-204,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的研究细菌性肝脓肿合并糖尿病与非合并糖尿病患者的病因和病原菌学分析。方法选择济南军区总医院2006年1月至2014年12月住院治疗细菌性肝脓肿患者共113例进行回顾性研究,糖尿病合并肝脓肿患者纳入糖尿病组,非糖尿病合并肝脓肿患者纳入研究的非糖尿病组,比较两者患者的一般资料、发病原因以及病原菌种类。结果糖尿病组患者的年龄[(62.5±11.0)岁]大于非糖尿病组[(54.4±14.8)岁],存在心血管疾病的比例(61.8%)高于非糖尿病组(36.7%)(P<0.05),发热时间和住院时间长于非糖尿病组,2组间差异无统计学意义(P>0.05);胆源性疾病及隐匿性感染在两组患者发病原因中所占比例相当(P>0.05);2组患者血液和脓液中大肠埃希菌、变形杆菌、铜绿假单胞菌、表皮葡萄球菌、链球菌、肠球菌的检出率比较差异无统计学意义(P>0.05);糖尿病组患者血液(47.4%)和脓液(64.0%)中肺炎克雷伯菌的检出率明显高于非糖尿病组(19.2%、36.3%),差异无统计学意义(P<0.05)。结论糖尿病合并肝脓肿患者年龄大于非糖尿病者,发热时间和住院时间延长,胆源性疾病及隐匿性感染是主要发病原因,肺炎克雷伯杆菌是最常见的病原菌。Objective To study the etiology and pathogens in diabetic and non-diabetic patients with hepatic abscess.Methods A total of 113 cases of hospitalized patients with bacterial liver abscess in Jinan Military General Hospital from January 2006 to December 2014 were enrolled.Diabetic patients with liver abscess were enrolled in diabetic group,non-diabetic patients with liver abscess patients were enrolled in non-diabetic group.Then general information, etiology and pathogens were compared.Results Diabetic patients [（62.5 ±11.0）years old]were elder than the non-diabetic group [（54.4 ±14.8）years old].The proportion of cardiovascular disease in diabetic group was higher than that in non-diabetic group（61.8%vs. 36.7%,P〈0.05）.Fever and hospitalization time of diabetic group were longer than those in non-diabetic group,but no statistical differences （ P〉0.05 ） .The proportions of biliary infection and hidden source of infection were equal in the two groups（P〉0.05）.There were no statistical differences of Escherichia coli, Proteus,Pseudomonas aeruginosa, Staphylococcus epidermidis, Streptococcus, enterococci in blood and pus between the two groups（P〉0.05）.The detection rates of Klebsiella pneumoniae in blood and pus in diabetic group （ 47.4%, 64.0%） were higher than those in non-diabetic group （ 19.2%, 36.3%;P 〈0.05 ） . Conclusion Diabetic patients with hepatic abscess are elder than non-diabetic patients, fever and hospitalization time are prolonged, biliary infection and hidden source of infection are the major causes, Klebsiella pneumoniae is the most common pathogen.

关 键 词：糖尿病 细菌性肝脓肿 病因 病原菌 

分 类 号：R575.4[医药卫生—消化系统]