大蒜素对蟾蜍离体心脏的作用机制探讨  

Allicin Mechanism of Toad on isolated rat hearts

作　　者：王藤[1] 刘子嘉[1] 祖有轩 单石磊[1] 梁翠茵[1] 

机构地区：[1]首都医科大学燕京医学院,101300

出　　处：《首都食品与医药》2016年第18期82-83,共2页Capital Food Medicine

基　　金：首都医科大学2015年第二课堂项目(项目编号:dekt2015140)

摘　　要：目的探究大蒜素对蟾蜍离体心脏的作用机制。方法采用斯氏离体蛙心灌流方法,通过BL420E描记心脏收缩力及心率变化,观察大蒜素溶液对离体心脏的心肌收缩力和心率的影响,并研究大蒜素对肾上腺素、氯化钙心肌收缩量效关系曲线的影响。结果 ①大蒜素溶液使蟾蜍离体心脏的心肌收缩力减弱,心率减慢。在1.652×10^-6-1.652×10^-2mol/L浓度范围内,大蒜素溶液抑制心肌收缩力的作用与剂量之间呈现明显的量效关系,最大效应可使心肌收缩力降低68%。②大蒜素溶液可使肾上腺素及氯化钙对心脏的兴奋作用降低。结论大蒜素溶液可抑制蟾蜍离体心脏的收缩力和心率,其作用可能与其抑制β受体,抑制细胞外钙内流有关。Objective To explore the allicin Isolated Heart of Toad mechanism. MethodsSri Lanka＇s isolated frog heart perfusion method, BL420 F tracings cardiac contractility and heart rate, and heart rate was observed on the allicin solution isolated heart myocardial contractility, and of allicin on adrenaline, calcium chloride myocardial contractility dose-response relationship curve. Results ①allicin solution enables Toad myocardial contractility weakened heart, slow the heart rate. Within 1.652×10^-6-1.652×10^-2 mol / L concentration range, allicin solution on the inhibition of myocardial contractility showed significant dose-response relationship between dose and effect, the maximum effect can reduce 68% of myocardial contractility. ②allicin solution allows stimulant epinephrine and calcium chloride on the heart is reduced. Conclusion： Allicin solution inhibits toad cardiac contractility and heart rate, and its effect may be related to inhibition of β receptor, inhibition of extracellular calcium influx.

关 键 词：大蒜素 心肌收缩力 心率 

分 类 号：R285[医药卫生—中药学]