新型复合矿化胶原膜用于牙槽嵴保存的实验研究  

Application of a new composite mineralized collagen membrane in alveolar ridge preservation in dogs

作　　者：孙翼[1] 王程越[1] 王彦夫[1] 陈展[2] 崔福斋[3] 

机构地区：[1]辽宁医学院附属口腔医院口腔修复科,锦州121000 [2]辽宁医学院附属口腔医院口腔颌面外科,锦州121000 [3]清华大学材料科学与工程系

出　　处：《实用口腔医学杂志》2016年第5期645-649,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:21371106)

摘　　要：目的:探讨新型复合矿化胶原膜用于犬拔牙位点牙槽嵴保存实验研究的可行性。方法:12只杂种犬拔除下颌双侧第三前臼齿,共有24个牙槽窝,将其随机分为3组,A组植入人工骨修复材料并覆盖新型复合矿化胶原膜,B组植入人工骨修复材料,C组为空白对照组。术后3个月通过大体观察、形态学测量、螺旋CT以及X射线显微CT检查评价牙槽窝愈合情况。结果:3个月时牙槽窝水平宽度和新骨小梁结构参数A组大于B组(P<0.05),B组大于C组(P<0.05);感兴趣区域CT值A组均高于B组和C组(P<0.05)。结论:新型复合矿化胶原膜可起到减缓牙槽嵴吸收、诱导新骨再生、保存牙槽嵴的作用。Objective： To study the feasibility of a new composite mineralized collagen membrane in alveolar ridge preservation. Methods： The third mandibular premolars on both sides were extracted from 12 dogs, the 24 alveolar sockets were randomly assigned into A, B and C groups（ n = 8 ）. The distal alveolar sockets of group A was immediately implanted with the new composite mineralized col- lagen membrane and bone graft material, those of group B with bone graft material, group C was the blank control. The healing of sockets was evaluated by gross observation, morphological measurements, X-ray microscope and photographs of spiral CT. Results： The horizontal width of the alveolar process of group A was bigger than that of group B （ P 〈 0.05 ）, that of group B was bigger than that of group C（P 〈0.05）. The region of extraction interest in spiral CT value was higher in group A than that in group B and C（P 〈0.05）. The extraction sockets were generated new bone and the degree of reconstruction measurements was higher in group A than that in group B and C （ P 〈 0. 05 ）. Conclusion： The new composite mineralized collagen membrane can induce the regeneration of new bone, and preserve the alveolar.

关 键 词：拔牙位点 矿化胶原 人工骨 牙槽嵴 

分 类 号：R783.6[医药卫生—口腔医学]