中药土三七致肝小静脉闭塞病六例临床分析及文献研究  

Clinical analysis and literature study on 6 cases of hepatic veno-occlusive disease caused by herbal soil notoginseng

作　　者：张亚杰[1] 汪颖厚[1] 田丰[1] 

机构地区：[1]中国医科大学附属盛京医院,沈阳110004

出　　处：《实用药物与临床》2016年第9期1137-1140,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨土三七致肝小静脉闭塞病(HVOD)的发病机制、临床表现、诊疗方法及体会。方法回顾性分析我院土三七致HVOD共6例患者的临床特点及诊治经过。结果 6例土三七致HVOD患者均以腹水腹胀为主要临床表现,同时伴有乏力、恶心、食欲减退、双下肢浮肿、轻度黄疸。结论土三七致HVOD的突出临床表现为大量腹水。增强CT及介入造影检查对本病的诊断及鉴别诊断有重要价值。目前治疗尚无特效方法,抗凝治疗存在争议。加强患者对中药的鉴别能力,规范合理用药,才能减少疾病发生。Objective To explore the pathogenesis, clinical manifestations, diagnosis and treatment methods of hepatic venous occlusion disease （HVOD） caused by herbal soil notoginseng. Methods The clinical characteristics and treatment of 6 patients diagnosed with HVOD caused by soil notoginseng in our hospital were retrospectively analyzed. Results Ascites and abdominal distension were the main clinical manifestations in all the 6 cases, accompanied by fatigue, nausea, anorexia, double lower limbs swelling and mild jaundice at the same time. Conclusion Vast ascites is the prominent clinical manifestation. Enhanced CT and interventional angiography imaging examination are valuable for diagnosis and differential diagnosis. Currently there is no specific treatment method, and anticoagulant therapy is controversial. Enhancing the patient＇s ability to identify traditional herbal medicine and rationally using drugs can reduce the occurrence of disease.

关 键 词：土三七 吡咯烷生物碱 肝小静脉闭塞病 

分 类 号：R575[医药卫生—消化系统]