TPO、CD56和GPC-3表达在甲状腺乳头状癌中的诊断价值  

The diagnostic value of expression of TPO protein,CD56 protein and GPC-3 protein in papillary thyroid carcinoma

作　　者：席民 胡向阳[1,3] 郑丽[4] 汪巧[1,3] Xi Min Hu Xiangyang Zheng Li et al(Dept of Pathology, Anhui Medical University, Hefei 230032 Dept of Pathology, Chuzhou City Vocational CoUege,Chuzhou 233100 Dept of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022 Dept of Pathology, The Second People＇s Hospital of Hefei ,Hefei 230011)

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]滁州城市职业学院病理教研室,滁州233100 [3]安徽医科大学第一附属医院病理科,合肥230022 [4]合肥市第二人民医院病理科,合肥230011

出　　处：《安徽医科大学学报》2016年第10期1539-1542,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家临床重点专科建设项目经费资助(编号:3101005004021)

摘　　要：目的探讨甲状腺过氧化物酶(TPO)、神经细胞黏附分子(CD56)与磷脂酰肌醇蛋白多糖-3(GPC-3)蛋白表达在甲状腺乳头状癌中的诊断价值。方法采用免疫组织化学Envision两步法检测80例甲状腺乳头状癌和77例甲状腺良性病变中TPO、CD56和GPC-3蛋白的表达。结果 80例甲状腺乳头状癌中的TPO、CD56和GPC-3的阳性表达率分别为11.2%、8.8%、88.8%,77例甲状腺良性病变中的阳性表达率分别为88.3%、93.5%、2.6%,两者比较差异有统计学意义(P<0.05)。三项标记物中,以CD56诊断灵敏度最高,达93.5%;以GPC-3诊断特异度最高,达97.4%。甲状腺乳头状癌中TPO、CD56和GPC-3蛋白的表达与患者性别、年龄、肿瘤直径、淋巴结转移等临床病理参数间均无相关性。结论 TPO、CD56和GPC-3在甲状腺乳头状癌与甲状腺良性病变的鉴别诊断中均有重要价值,联合检测尤其是联合灵敏度最高的CD56及特异度最高的GPC-3,更能提高甲状腺乳头状癌诊断的准确性。Objective To evaluate the diagnostic value of TPO, CD56 and GPC-3 in papillary thyroid carcinoma （PTC）. Methods Immunohistochemieal staining was performed in 80 specimens of PTC and 77 specimens of pa- pillary benign lesions to examine the expression of TPO protein, CD56 protein and GPC-3 protein. Results The positive ratios of TPO, CD56 and GPC-3 were 11. 2% , 8.8% and 88.8% in PTC, respectively, and their positive ratios in benign lesions were 8g. 3% , 93.5% and 2.6%. There were all statistical difference between them（P 〈 0. 05）. The one which had highest diagnostic sensitivity was CD56 and it could reach 93.5% ; the one which had highest diagnostic specificity was GPC-3 and it could reach 97.4% in three makers. There were no relationships between expression of TPO, CD56 and GPC-3 and the clinieopothological features including patients＇ gender, age, tumor diameter and lymph node metastasis in PTC. Conclusion To evaluate the expression of TPO, CD56 and GPC-3 protein may provide reference value for the diagnosis of PTC and benign lesions. GPC-3, the one which has highest diagnostic specificity, combined with CD56 which has the highest diagnostic sensitivity of PTC, may further improve diagnostic accuracy of the PTC.

关 键 词：甲状腺乳头状癌 TPO CD56 GPC-3 

分 类 号：R736.1[医药卫生—肿瘤]