夜间睡眠时间与女性乳腺癌发病风险的前瞻性队列研究  

Association between sleep duration and the risk of female breast cancer incidence:aprospective cohort study

作　　者：杨文静[1] 冯小双[1] 王刚[2] 吕章艳 谢双华 陈朔华[3] 阴建[1] 秘子涵 王珅 任建松[1] 石菊芳[1] 李霓[1] 陈玉恒[1] 吴寿岭[3] 代敏[1] 

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院,北京100021 [2]开滦总医院肿瘤科,河北唐山063000 [3]开滦总医院开滦员工健康保障中心,河北唐山063000 [4]哈尔滨医科大学公共卫生学院流行病学教研室,黑龙江哈尔滨150081 [5]中国医科大学流行病学教研室,辽宁沈阳110122

出　　处：《中华肿瘤防治杂志》2016年第14期903-908,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：2014年公益性行业科研专项(201402003);国家自然科学基金(81673265;81172757;81373079);北京科技新星计划(xx2012067);协和青年基金(33320140168)

摘　　要：目的我国女性乳腺癌发病率逐年上升,夜间睡眠时间长短可能与一系列健康效应相关,为探究夜间睡眠时间与乳腺癌发病关联性,本研究以唐山开滦集团前瞻性动态队列中的女性人群为基础进行了相关分析。方法采用2006-2011年开滦集团体检人群中女性人群资料,收集社会人口学资料、睡眠习惯、身高、体质量等基线信息及乳腺癌发病结局信息。采用Cox比例风险回归模型分析夜间睡眠时间与女性乳腺癌发病风险的关联性。结果共纳入24 692名女性体检者,总随访108 029.22人年,平均随访时间为4.38年,新发乳腺癌病例107例。以夜间睡眠7h为参比组,单因素分析提示夜间睡眠偏短(≤6h,HR=0.99,95%CI=0.52~1.87)或偏长(≥8h,HR=0.84,95%CI=0.49~1.45)与乳腺癌发病风险无统计学关联。调整年龄、受教育程度、饮酒等混杂因素后,分析仍显示夜间睡眠时间偏短(HR=0.82,95%CI=0.43~1.56)或偏长(HR=0.94,95%CI=0.54~1.64)与女性乳腺癌的发病无统计学关联。按年龄、打鼾情况和BMI分层分析及敏感性分析后,结果仍未发现存在显著性关联。结论本研究结果尚不支持夜间睡眠时间偏短或偏长与女性乳腺癌的发病风险存在关联性。OBJECTIVE Breast cancer incidence among Chinese females has been increased for decades. In order to evaluate the association between sleep duration and female breast cancer incidence, Kailuan prospective cohort was applied as the basis of this study. METHODS Among females in Kailuan health detection program during 2006-2011, baseline information such as demography, sleeping habits, height and weight were collected, as well as the information of newly- diagnosed breast cancer cases during the follow up period. Cox proportional risk regression model was applied to evaluate the risk ratio of sleep duration and female breast cancer incidence. RESULTS A total of 24 692 women were recruited in this study, and there were 108 029.22 person-years of follow up and 4.38 years of average follow-up duration. During the follow-up period, 107 breast cancer were newly indentified in this cohort. Compared with females with 7-hour sleep dura- tion, females with insufficient sleep （≤6 h） or longer sleep （≥8 h） duration showed no significant relation to breast cancer incidence （HR=0.99, 95%CI=0.52-1.87; HR=0.84, 95%CI=0.49-1.45）, after adjusting with age, edu- cation level, alcohol drinking, and the other confounding factors, the results also showed no statistical association （insuf- ficient sleep： HR=0.82, 95%CI=0.43-1.56; longer sleep.. HR=0.94, 95%CI=0. 54-1. 64）. Similar results were obtained in subgroup analysis, which stratified by age, snoring, or BMI, and sensitivity analysis. CONCLUSION Our study don^t support that sleep duration is significantly associated with the risk of female breast cancer.

关 键 词：夜间睡眠时间 女性乳腺癌 前瞻性队列 

分 类 号：R737.9[医药卫生—肿瘤]