癌痛散在恶性肿瘤骨转移疼痛治疗中的临床研究  

Clinical observation of pain control in malignment tumor with bone metastases by aitong powber

作　　者：杨忠明[1,2] 谢刚[3] 廖大忠 彭磊[2] 梅琳[2] 宋瑞蓉 邱燕[2] 

机构地区：[1]西南医科大学附属中医医院肿瘤科,四川泸州646000 [2]四川省彭州市中医医院肿瘤科,611930 [3]四川省中西医结合医院肿瘤科,成都610041

出　　处：《重庆医学》2016年第28期3893-3895,3899,共4页Chongqing medicine

基　　金：四川省中医药管理局科研基金资助项目(2014-C-049);四川省卫生厅科研基金资助项目(120170)

摘　　要：目的观察癌痛散在恶性肿瘤骨转移疼痛治疗中的疗效并分析其意义。方法 220例癌痛患者分为试验组115例和对照组105例;其中,轻度癌痛,试验组31例采用复方中药癌痛散外敷治疗,对照组30例采用布洛芬缓释片治疗;中重度癌痛,试验组84例采用癌痛散联合盐酸吗啡缓释片治疗,对照组75例单用盐酸吗啡缓释片治疗。观察疼痛程度、止痛起效时间、持续时间和Karnofsky评分等;监测血常规、肝肾功能、心电图及异常症状等安全性指标。结果轻度癌痛,试验组与对照组疗效相当(P>0.05);中重度癌痛,试验组止痛效果明显优于对照组(P<0.05)。全部病例不良反应比较,试验组优于对照组(P<0.05)。结论癌痛散可以改善恶性肿瘤骨转移疼痛,轻度癌痛可以替代布洛芬治疗,中重度癌痛联合盐酸吗啡缓释片疗效更好,并且安全性高,不良反应少,可以提高生活质量。Objective To study the curative effect and the significance of cancer pain treatment by aitong powber in malignant tumors with bone metastases. Methods Totally 220 cases with cancer pain for bone metastases were included, and divided into treatment group（n=115）and Contro group（n=105）. In those cases with mild cancer pain, 31 cases by aitong powber in treatment group and 30 cases by ihuprofen sustained-release tablets m control group;While in those cases with moderately and severe pain, 84 cases by morphine hydroehloride sustained-release tablets combined with aitong powber in treatment group and 75 cases by only morphine hydrochloride sustained-release tablets in control group. The degree of pain, the pain working time, duration and karnofsky scores were obversed as clinical indicator;peripheral blood,liver and kidney function, electrocardiogram and abnormal symptoms were observed as safety indexes. Results The curative effect of mild pare cases in treatment group was similar to control group （P〉0.05） ,curative effect of moderately and severe pain cases in treatment group was superior to control group（P〈0.05）,safety indexes of all cases compassion, the whole treatment group was superior to the whoie control group（P〈0.05）. Conclusion Aitong powber may control cancer pain;the curative effect is approximate between aitong powber and ibuprofen sustained-release tablets, and aitong powber may replace ibuprofen treatment in those cases with mild pain. For moderately and severe pain,aitong powber combined with morphine hydrochloride sustained-release tablets is superior to the only morphine hydrochloride sustained-re/ease tablets in pain control. Aitong powber may＇improve the quality of life,and lower adverse reactions and higher security.

关 键 词：恶性肿瘤 骨转移 癌性疼痛 癌痛散 布洛芬缓释片 盐酸吗啡缓释片 

分 类 号：R730.5[医药卫生—肿瘤]