大蒜素对老年高脂血症患者血脂及体质量指数的影响  

Effects of garlic on body mass index and serum lipids in elderly patients with hyperlipidemia

作　　者：王瑞[1] 樊颍 肖林平[1] 陈鹰军[1] 张卫国[1] 贺东风[1] 李泱[3] 

机构地区：[1]解放军451医院门诊部,陕西西安710054 [2]空军装备研究院门诊部,北京100085 [3]解放军总医院老年心血管病研究所,北京100853

出　　处：《心脏杂志》2016年第5期565-567,共3页Chinese Heart Journal

摘　　要：目的探讨大蒜素对老年高脂血症患者体质量指数(BMI)及血脂水平的影响。方法选择门诊就诊血脂异常的老年患者,将符合标准160例患者分为试药组(n=80)和安慰剂组(n=80),试药组予大蒜素胶囊,安慰剂组服用安慰剂胶囊;观察两组治疗前后一般状况、BMI、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肝、肾功能等的变化。结果 127例患者完成治疗,其中试药组65例,安慰剂组62例;试药组TC(4.8±1.3)mmol/L、TG(1.4±1.1)mmol/L、LDL-C(2.6±0.7)mmol/L、BMI(25.1±5.2)均显著低于安慰剂组(均P<0.05),HDL-C(1.5±0.7)mmol/L显著高于安慰剂组(P<0.05)。结论大蒜素能有效降低老年高脂血症患者血脂水平。AIM To observe the effects of garlic on body mass index and serum lipids in elderly hyper- lipidemia patients. METHODS One hundred and sixty elderly hyperlipidemia patients were divided into treatment group （ n = 80） and control group （ n = 80）. The treatment group was treated with garlic capsules, whereas the control group was treated with placebo capsules. The general status, body mass index （BMI）, serum total cholesterol （TC）, serum triglycerides （TG）, low-density lipoprotein choles- terol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, blood viscosity, and liver and kidney functions were compared before and after treatment. RESULTS One hundred and twenty-seven patients completed the treatment. In the treatment group （n = 65）, BMI, TC, TG and LDL-C were, respectively, （25.1 ± 5.2 ）, （4. 8 ± 1.3 ） mmol/L, （ 1.4 ± 1.1 ） mmol/L and （ 2. 6± 0.7 ） mmol/L, lower than those in the control group （n =62）, and HDL-C was （1.5 ±0. 7） mmol/L, higher than that in the control group （P 〈 0. 05 ）. CONCLUSION Garlic compared with placebo can effectively reduce serum lipids and body mass index in elderly hyperlipidemie patients.

关 键 词：大蒜素 高脂血症 血脂 体质量指数 老年 

分 类 号：R972.6[医药卫生—药品]