协同刺激分子B7-H4在消化系统肿瘤中的研究进展  

Research Progress of Costimulatory Molecule B7-H4 in Digestive System Neoplasms

作　　者：丁雪[1] 李晓梅[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150081

出　　处：《中国肿瘤》2016年第9期706-710,共5页China Cancer

摘　　要：协同刺激分子B7-H4是B7家族的一个新成员,它通过抑制T细胞的增殖活化、阻碍细胞因子的合成和细胞周期的进程来下调免疫应答。B7-H4广泛分布在非淋巴组织中,高表达于多种恶性肿瘤并参与肿瘤的发生发展及预后。B7-H4在消化道系统肿瘤中的高表达可能使其成为新的肿瘤标志物及早期诊断指标,为免疫治疗提供新的依据。全文就消化道系统肿瘤中B7-H4的研究进展进行综述。Costimulatory molecule B7-H4 is a new member of B7 family.h can negatively regulate T cells immune response by suppressing the proliferation,activation and cytokine production of T cells. B7-H4 is widely distributed in non-lymphoid tissues and high expression in a variety of ma- lignancies and involved in tumor progression and prognosis. B7-H4 will be a new tumor marker due to the high expression in digestive system neoplasms. It is expected to be the early diagnosis of digestive system neoplasms,and providing new strategies for immunotherapy. The recent progress of B7-H4 research in digestive system neoplasms was reviewed in this article.

关 键 词：B7-H4 协同刺激分子 消化道系统肿瘤 T细胞 免疫逃逸 

分 类 号：R735[医药卫生—肿瘤]